<p>Ferroptosis is an iron-dependent form of regulated cell death with increasing relevance to pharmacology, particularly in cancer therapy, neuroprotection, and metabolic disease modulation. Despite the rapid growth of the field, existing bibliometric studies remain fragmented, disease-specific, and largely confined to Web of Science databases, with limited coverage beyond 2023. This study presents a comprehensive dual-dataset Scopus-based bibliometric analysis of ferroptosis research (2012–2025), comprising 12,846 original articles representing the global landscape and 1797 pharmacologically enriched articles focused on therapeutic development. Using Bibliometrix, VOSviewer, and CiteSpace, the analysis evaluates publication trends, geographic distribution, collaboration networks, keyword co-occurrence, thematic evolution, and strategic mapping based on Bradford’s Law and Callon’s density-centrality metrics, characterizing publication dynamics, intellectual structure, translational trajectories, and pharmacological innovation patterns relevant to drug discovery. Results revealed exponential growth in output, particularly after 2020, with China contributing the largest share of publications, while Western countries demonstrated higher citation impact. Core mechanistic themes centered on GPX4, oxidative stress, and lipid peroxidation, whereas recent thematic evolution highlights increasing emphasis on immunotherapy, prognostic biomarkers, and non-oncological degenerative diseases. Pharmacological thematic mapping identified doxorubicin cardiotoxicity as a dominant motor theme, with sorafenib, network pharmacology, and ubiquitination emerging as foundational therapeutic constructs. This analysis positions ferroptosis as a mature and rapidly expanding pharmacological research domain, identifies key translational frontiers, and provides a strategic framework to guide future drug discovery and therapeutic development.</p>