Scholarlink

<p><i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) is a predominant pathogen responsible for severe nosocomial infections, with rising multidrug resistance posing a critical threat to global health. Despite the promise of vaccination, antigenic diversity and complex virulence mechanisms involving multiple biomacromolecules have impeded the development of an effective vaccine. This study aims to map the research landscape of <i>P. aeruginosa</i> vaccine development.&#xa0;A comprehensive bibliometric analysis of 1701 publications from the Web of Science (WOS) and PubMed database (1970–2025) was conducted using VOSviewer and CiteSpace.&#xa0;A pronounced increase in annual publication output following 2013 was observed, with the USA and China identified as the principal contributors. Keyword clustering and burst detection analyses revealed emerging research foci on multi-epitope vaccine constructs, biomacromolecule-based antigen design, including outer membrane proteins, polysaccharides, and vesicles, and innovative delivery platforms such as nanoparticles. Contemporary investigations emphasize structural vaccinology, reverse immunology methodologies, and the application of biodegradable polymers for antigen encapsulation.&#xa0;Overall, this study reveals shifting research priorities and offers a data-driven framework to inform future research directions of <i>P. aeruginosa</i> vaccine development. Notably, the convergence of computational vaccine design with advanced macromolecular delivery systems presents substantial promise for the development of broadly protective vaccines against <i>P. aeruginosa</i>.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bibliometric analysis of Pseudomonas aeruginosa vaccine development highlighting research status, evolution, and future opportunities

  • 期刊论文

  • 发表日期：

    2026年1月7日

查看全文
  • Shiqin Huang,
  • Yi Zhou,
  • Meiling Wu,
  • Xinyan He,
  • Jie Liu,
  • Xinyao Chen,
  • Chunyong Xia,
  • Wen Wu,
  • Ying Fan

摘要

Pseudomonas aeruginosa (P. aeruginosa) is a predominant pathogen responsible for severe nosocomial infections, with rising multidrug resistance posing a critical threat to global health. Despite the promise of vaccination, antigenic diversity and complex virulence mechanisms involving multiple biomacromolecules have impeded the development of an effective vaccine. This study aims to map the research landscape of P. aeruginosa vaccine development. A comprehensive bibliometric analysis of 1701 publications from the Web of Science (WOS) and PubMed database (1970–2025) was conducted using VOSviewer and CiteSpace. A pronounced increase in annual publication output following 2013 was observed, with the USA and China identified as the principal contributors. Keyword clustering and burst detection analyses revealed emerging research foci on multi-epitope vaccine constructs, biomacromolecule-based antigen design, including outer membrane proteins, polysaccharides, and vesicles, and innovative delivery platforms such as nanoparticles. Contemporary investigations emphasize structural vaccinology, reverse immunology methodologies, and the application of biodegradable polymers for antigen encapsulation. Overall, this study reveals shifting research priorities and offers a data-driven framework to inform future research directions of P. aeruginosa vaccine development. Notably, the convergence of computational vaccine design with advanced macromolecular delivery systems presents substantial promise for the development of broadly protective vaccines against P. aeruginosa.