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<p>Placental injury is a hazardous problem that impacts pregnancy and fetal growth. Cyclophosphamide (CP) is chemotherapeutic agent which is used in the therapy of autoimmune diseases and some tumors. Unfortunately, CP affects tumor cells and normal cells causing damage to several organs including placenta. This study aimed to investigate the effect of cetirizine (CZ), on CP-induced placental injury.&#xa0;48 female rats were divided into 8 groups (n = 6 rats each). Group I: control group; Group II: CZ 5&#xa0;mg-treated rats; Group III: CZ 10&#xa0;mg-treated rats; Group IV: CZ 20&#xa0;mg-treated rats; Group V: rats received CP (20&#xa0;mg/kg, i.p); Group VI: rats were administered CZ5 mg plus CP; Group VII: rats were received CZ10 mg plus CP; Group VIII: rats were administered CZ20 mg plus CP. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant capacity (TAC) in placental tissue, placental growth factor (PlGF), NADP oxidase 4 (NOX4) and caspase-3 were measured. Histological changes, transforming growth factor-β (TGF-β) immuno-expression were also evaluated.&#xa0;CZ caused a significant reduction in placental oxidative stress, inflammation and apoptosis induced by CP.&#xa0;Current study revealed that CZ protective role against CP-induced placental damage involves modulation of TGF-β/NOX4 signaling pathway (Fig.&#xa0;<InternalRef RefID="Fig1">1</InternalRef>). </p>

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Cetirizine ameliorates cyclophosphamide-induced placental toxicity via modulation of TGF-β/NOX4 signaling pathway in rats

  • 期刊论文

  • 发表日期：

    2025年11月29日

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  • Salwa Abdeltwab Ibrahim,
  • Walaa Yehia Abdelzaher,
  • Asmaa Mohamed Abdel-Aziz,
  • Rania Rady Fadl,
  • Hanaa Hassanein Mohammed,
  • Seham Abdel-Wakeel Abdel-Gaber

摘要

Placental injury is a hazardous problem that impacts pregnancy and fetal growth. Cyclophosphamide (CP) is chemotherapeutic agent which is used in the therapy of autoimmune diseases and some tumors. Unfortunately, CP affects tumor cells and normal cells causing damage to several organs including placenta. This study aimed to investigate the effect of cetirizine (CZ), on CP-induced placental injury. 48 female rats were divided into 8 groups (n = 6 rats each). Group I: control group; Group II: CZ 5 mg-treated rats; Group III: CZ 10 mg-treated rats; Group IV: CZ 20 mg-treated rats; Group V: rats received CP (20 mg/kg, i.p); Group VI: rats were administered CZ5 mg plus CP; Group VII: rats were received CZ10 mg plus CP; Group VIII: rats were administered CZ20 mg plus CP. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant capacity (TAC) in placental tissue, placental growth factor (PlGF), NADP oxidase 4 (NOX4) and caspase-3 were measured. Histological changes, transforming growth factor-β (TGF-β) immuno-expression were also evaluated. CZ caused a significant reduction in placental oxidative stress, inflammation and apoptosis induced by CP. Current study revealed that CZ protective role against CP-induced placental damage involves modulation of TGF-β/NOX4 signaling pathway (Fig. 1).