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<p>A new class of tiny non-coding RNAs (ncRNAs) known as tRNA-derived fragments (tRFs) is produced when mature tRNAs or tRNA precursors are cleaved. The discovery of more and more tRFs with essential roles in many physiological and pathological processes has been made possible by advancements in high-throughput sequencing. tRFs are considered important regulators of human disorders, particularly cancer, because they may control cell viability, differentiation, and homeostasis via various methods. Furthermore, there is growing evidence that extracellular tRFs could be used as potential biomarkers for cancer liquid biopsy diagnosis and prognosis. The biogenesis, categorization, and alteration of tRFs are the main topics of this review. We also provide an overview of the various roles that tRFs play in breast cancer (BC), focusing on the state of studies and future directions for tRFs in this field.</p>

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Unlocking the role of tRNA-derived fragments in shaping breast cancer signaling

  • 期刊论文

  • 发表日期：

    2025年7月21日

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  • Chou-Yi Hsu,
  • Saade Abdalkareem Jasim,
  • Renuka S. Jyothi,
  • Irfan Ahmad,
  • Ahmed Hjazi,
  • Mahmood Hasen Shuhata Alubiady,
  • Aashna Sinha,
  • Yasser Fakri Mustafa,
  • Ahmed Muzahem Al-Ani,
  • Ahmed Hussn

摘要

A new class of tiny non-coding RNAs (ncRNAs) known as tRNA-derived fragments (tRFs) is produced when mature tRNAs or tRNA precursors are cleaved. The discovery of more and more tRFs with essential roles in many physiological and pathological processes has been made possible by advancements in high-throughput sequencing. tRFs are considered important regulators of human disorders, particularly cancer, because they may control cell viability, differentiation, and homeostasis via various methods. Furthermore, there is growing evidence that extracellular tRFs could be used as potential biomarkers for cancer liquid biopsy diagnosis and prognosis. The biogenesis, categorization, and alteration of tRFs are the main topics of this review. We also provide an overview of the various roles that tRFs play in breast cancer (BC), focusing on the state of studies and future directions for tRFs in this field.