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<p>We studied how hypothermia and hyperthermia may change the efficacy and/or potency of dopamine to augment the force of contraction in atria of mice with cardiac overexpression of the human D<sub>1</sub>-dopamine receptor (D<sub>1</sub>-TG). We measured the force of contraction on paced (1&#xa0;Hz) left atria and spontaneously beating right atria of these D<sub>1</sub>-TG mice in vitro. The intrinsic heart beat in the right atria from D<sub>1</sub>-TG mice lowered when we reduced the temperature (24&#xa0;°C, hypothermia) and elevated when we raised the temperature (42&#xa0;°C, hyperthermia) in the organ baths. In addition, the efficacy of dopamine (0.001–100&#xa0;µM) to augment the force of contraction was diminished in the left and right D<sub>1</sub>-TG mouse atrial preparations under 24&#xa0;°C and 42&#xa0;°C compared to 37&#xa0;°C in the organ baths. Likewise, the rise in force after dopamine was diminished at 24&#xa0;°C and 42&#xa0;°C compared to 37&#xa0;°C in paced human atrial preparations (HAP) obtained from patients who underwent surgery. In conclusion, the inotropic effects of dopamine in D<sub>1</sub>-TG mice and in human atrial preparation via D<sub>1</sub>-dopamine receptors, but also the effects of dopamine in D<sub>1</sub>-TG mice on the heartbeat, change with ambient temperature.</p>

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Temperature alters the inotropic and chronotropic effect of D1-dopamine receptor stimulation in the mammalian atrium

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月30日

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  • Peter Grundig,
  • Thanh Hoai Pham,
  • Britt Hofmann,
  • Joachim Neumann,
  • Ulrich Gergs

摘要

We studied how hypothermia and hyperthermia may change the efficacy and/or potency of dopamine to augment the force of contraction in atria of mice with cardiac overexpression of the human D1-dopamine receptor (D1-TG). We measured the force of contraction on paced (1 Hz) left atria and spontaneously beating right atria of these D1-TG mice in vitro. The intrinsic heart beat in the right atria from D1-TG mice lowered when we reduced the temperature (24 °C, hypothermia) and elevated when we raised the temperature (42 °C, hyperthermia) in the organ baths. In addition, the efficacy of dopamine (0.001–100 µM) to augment the force of contraction was diminished in the left and right D1-TG mouse atrial preparations under 24 °C and 42 °C compared to 37 °C in the organ baths. Likewise, the rise in force after dopamine was diminished at 24 °C and 42 °C compared to 37 °C in paced human atrial preparations (HAP) obtained from patients who underwent surgery. In conclusion, the inotropic effects of dopamine in D1-TG mice and in human atrial preparation via D1-dopamine receptors, but also the effects of dopamine in D1-TG mice on the heartbeat, change with ambient temperature.