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<p>This study investigates the anti-inflammatory and antinociceptive effects of gamma-terpinene (GT), a monoterpene present in essential oils, in models of acute joint inflammation and pain. GT was administered orally at doses of 25, 50, 75, and 100 mg/kg. Joint inflammation was induced by an intra-articular injection of zymosan to assess joint edema, leukocyte migration, and myeloperoxidase (MPO) enzyme activity. A carrageenan-induced paw edema model was used to evaluate edema and mechanical hyperalgesia, with measurements taken via plethysmometry and Von Frey testing. Results showed that GT significantly decreased leukocyte migration, joint edema, and MPO activity in the zymosan model, indicating an anti-inflammatory effect. In the carrageenan model, GT also demonstrated a dose-dependent reduction in paw edema and mechanical hyperalgesia, highlighting its analgesic potential. These findings support that GT possesses notable anti-inflammatory and antinociceptive properties, making it a promising candidate for natural therapeutic applications in managing inflammatory joint conditions. This suggests a potential role of GT as a natural alternative to NSAIDs and glucocorticoids (GCs), reducing inflammation while minimizing side effects. Future studies should explore its clinical applicability and long-term safety.</p>

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Effect of gamma-terpinene on the articular inflammatory response

  • 期刊论文

  • 发表日期：

    2025年4月15日

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  • Guilherme Henrique Oliveira Silva,
  • Camila Ferreira Amaral,
  • Edvalkia Magna Teobaldo da Rocha,
  • Roberto Kenji Nakamura Cuman,
  • Francielli Maria de Souza Silva Comar

摘要

This study investigates the anti-inflammatory and antinociceptive effects of gamma-terpinene (GT), a monoterpene present in essential oils, in models of acute joint inflammation and pain. GT was administered orally at doses of 25, 50, 75, and 100 mg/kg. Joint inflammation was induced by an intra-articular injection of zymosan to assess joint edema, leukocyte migration, and myeloperoxidase (MPO) enzyme activity. A carrageenan-induced paw edema model was used to evaluate edema and mechanical hyperalgesia, with measurements taken via plethysmometry and Von Frey testing. Results showed that GT significantly decreased leukocyte migration, joint edema, and MPO activity in the zymosan model, indicating an anti-inflammatory effect. In the carrageenan model, GT also demonstrated a dose-dependent reduction in paw edema and mechanical hyperalgesia, highlighting its analgesic potential. These findings support that GT possesses notable anti-inflammatory and antinociceptive properties, making it a promising candidate for natural therapeutic applications in managing inflammatory joint conditions. This suggests a potential role of GT as a natural alternative to NSAIDs and glucocorticoids (GCs), reducing inflammation while minimizing side effects. Future studies should explore its clinical applicability and long-term safety.