<p>Omentin-1, a novel adipocytokine predominantly secreted by visceral adipose tissue, has emerged as a significant factor in cardiovascular health, particularly regarding hypertension (HTN) and heart failure (HF). This manuscript investigates the multifaceted roles of omentin-1 in these conditions, emphasizing its protective effects on vascular function and its potential as both a biomarker and therapeutic target. Clinical studies indicate that reduced circulating levels of omentin-1 are associated with metabolic syndrome (MetS) and increased cardiovascular risk, while animal studies demonstrate its ability to ameliorate endothelial dysfunction and lower blood pressure. Omentin-1 exerts its beneficial effects through various signaling pathways, including AMP-activated protein kinase (AMPK) and protein kinase B (Akt), thereby promoting vasodilation, enhancing insulin sensitivity, and mitigating inflammation. In the context of HF, particularly heart failure with preserved ejection fraction (HFpEF), omentin-1 levels exhibit a negative correlation with diastolic dysfunction and inflammatory markers, suggesting its role in cardiac protection. Additionally, the manuscript discusses the implications of omentin-1 in managing obesity-related cardiovascular diseases and its potential utility as a prognostic marker for adverse outcomes in HF patients. Collectively, omentin-1 represents a promising avenue for research in cardiovascular health, with the potential to inform novel therapeutic strategies aimed at improving outcomes in patients with HTN and HF. Further research is necessary to elucidate the details of omentin-1 function and evaluate its potential in the treatment of cardiovascular disease.</p> Graphical abstract <p>Omentin-1 is an adipokine secreted from adipose tissue that plays crucial roles in cardiovascular health. This protein demonstrates significant cardioprotective effects by reducing inflammation, cardiac hypertrophy, and myocardial infarction risks. On the vascular side, Omentin-1 helps improve endothelial function while reducing arterial stiffness, vascular tone, and insulin resistance. Notably, patients suffering from heart failure and hypertension typically show lower levels of Omentin-1 compared to healthy individuals. The therapeutic potential of Omentin-1 is particularly promising, as treatment with this protein has shown effectiveness in improving patient outcomes. The diagram illustrates how Omentin-1 functions as a mediator between adipose tissue and cardiovascular health through multiple pathways. The protein’s dual action on both cardiac and vascular systems makes it an important target for cardiovascular disease treatment. The upward and downward arrows in the figure effectively demonstrate how Omentin-1 enhances beneficial functions while suppressing harmful cardiovascular conditions.</p> <p></p>