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<p>Identifying natural substances that regulate microRNAs (miRNAs) has facilitated the development of innovative therapeutic strategies for brain cancer therapy. This work investigates the intricate interaction between miRNA expression and the specified chemicals, aiming to comprehend how natural compounds may modify miRNA profiles to affect carcinogenic pathways. Curcumin and resveratrol are natural compounds that have lately shown anticancer effects. These drugs function by modifying the expression of certain miRNAs linked to tumor proliferation and treatment resistance. Natural therapies can target these miRNAs, potentially improving therapy effectiveness and mitigating the adverse effects often linked to conventional pharmaceuticals. This review collects the latest findings on the impact of natural compounds on miRNAs. It presents an innovative approach to brain cancer treatment by leveraging the bioactivity of these substances to reinstate normal miRNA function. Natural chemicals provide a comprehensive strategy for addressing brain cancer, underscoring their significance in transforming future therapeutics. From this perspective, natural compounds provide a means to combat brain cancer.</p>

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Natural compounds as regulators of miRNAs: exploring a new avenue for treating brain cancer

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • Ahmed S. Doghish,
  • Walaa A. El-Dakroury,
  • Ahmed I. Abulsoud,
  • Nourhan M. Abdelmaksoud,
  • Shaza H. Aly,
  • Abdullah M. M. Elbadry,
  • Osama A. Mohammed,
  • Mustafa Ahmed Abdel-Reheim,
  • Mohamed Bakr Zaki,
  • Nehal I. Rizk,
  • Esraa M. Mosalam,
  • Amany S. EL-Khouly,
  • Sherif S. Abdel Mageed

摘要

Identifying natural substances that regulate microRNAs (miRNAs) has facilitated the development of innovative therapeutic strategies for brain cancer therapy. This work investigates the intricate interaction between miRNA expression and the specified chemicals, aiming to comprehend how natural compounds may modify miRNA profiles to affect carcinogenic pathways. Curcumin and resveratrol are natural compounds that have lately shown anticancer effects. These drugs function by modifying the expression of certain miRNAs linked to tumor proliferation and treatment resistance. Natural therapies can target these miRNAs, potentially improving therapy effectiveness and mitigating the adverse effects often linked to conventional pharmaceuticals. This review collects the latest findings on the impact of natural compounds on miRNAs. It presents an innovative approach to brain cancer treatment by leveraging the bioactivity of these substances to reinstate normal miRNA function. Natural chemicals provide a comprehensive strategy for addressing brain cancer, underscoring their significance in transforming future therapeutics. From this perspective, natural compounds provide a means to combat brain cancer.