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<p>The progression of periodontal disease (PD) involves the action of oxidative stress mediators. Antioxidant agents may potentially attenuate the development of this condition. Thus, we aimed to evaluate the effects of different doses of humic acid (HA), extracted from biomass vermicomposting, on redox status and parameters related to PD progression in rats. Fifty-four adult male Wistar rats were distributed into six experimental groups (control; PD; PD + 40&#xa0;mg/kg of HA; PD + 80&#xa0;mg/kg of HA; PD + 160&#xa0;mg/kg of HA; PD + 320&#xa0;mg/kg of HA). HA was administered by gavage for 28&#xa0;days, and PD was induced by ligature on the mandibular first molars on the 14th day of treatment. After euthanasia, alveolar bone loss, oxidative stress in the gum and erythrocytes, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine were analyzed. Animals treated with HA showed less bone loss at the dose of 80&#xa0;mg/kg compared to the untreated PD group (<i>p</i> &lt; 0.05). Animals treated with HA at doses higher than 80&#xa0;mg/kg showed improvements in local and systemic redox status parameters (total antioxidant activity, thiobarbituric reactive substances, carbonyl derivatives, and superoxide dismutase) compared to the PD group (<i>p</i> &lt; 0.05). Treatment with HA reduced serum levels of creatinine (at doses of 80 and 160&#xa0;mg/kg) and AST (at doses of 40 and 80&#xa0;mg/kg) compared to the PD group (<i>p</i> &lt; 0.05). HA treatment attenuated alveolar bone loss and improved local and systemic oxidative stress parameters in ligature-induced PD rats.</p> Graphical Abstract <p></p>

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Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis

  • 期刊论文

  • 发表日期：

    2025年1月10日

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  • Hugo Giordano Tavares,
  • Patrícia Ribeiro Orlando,
  • Ramona Ramalho de Souza Pereira,
  • Caíque Olegário Diniz e Magalhães,
  • Gabriela Silva,
  • Alice dos Santos Nunes Ferreira,
  • Bruna Caroline Chaves Garcia,
  • Karen Rodrigues Lima,
  • Etel Rocha Vieira,
  • Leonardo Barros Dobbss,
  • Marco Fabrício Dias-Peixoto,
  • Alan Rodrigues Teixeira Machado,
  • Luciano José Pereira,
  • Eric Francelino Andrade

摘要

The progression of periodontal disease (PD) involves the action of oxidative stress mediators. Antioxidant agents may potentially attenuate the development of this condition. Thus, we aimed to evaluate the effects of different doses of humic acid (HA), extracted from biomass vermicomposting, on redox status and parameters related to PD progression in rats. Fifty-four adult male Wistar rats were distributed into six experimental groups (control; PD; PD + 40 mg/kg of HA; PD + 80 mg/kg of HA; PD + 160 mg/kg of HA; PD + 320 mg/kg of HA). HA was administered by gavage for 28 days, and PD was induced by ligature on the mandibular first molars on the 14th day of treatment. After euthanasia, alveolar bone loss, oxidative stress in the gum and erythrocytes, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine were analyzed. Animals treated with HA showed less bone loss at the dose of 80 mg/kg compared to the untreated PD group (p < 0.05). Animals treated with HA at doses higher than 80 mg/kg showed improvements in local and systemic redox status parameters (total antioxidant activity, thiobarbituric reactive substances, carbonyl derivatives, and superoxide dismutase) compared to the PD group (p < 0.05). Treatment with HA reduced serum levels of creatinine (at doses of 80 and 160 mg/kg) and AST (at doses of 40 and 80 mg/kg) compared to the PD group (p < 0.05). HA treatment attenuated alveolar bone loss and improved local and systemic oxidative stress parameters in ligature-induced PD rats.

Graphical Abstract