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<p>Regulated cell death (RCD) is a fundamental biological process essential for tissue homeostasis and disease regulation. Increasing evidence has demonstrated that RCD plays a pivotal role in the pathogenesis of uterine endometrial diseases, including endometriosis, abnormal decidualization, endometrial receptivity defects, and intrauterine adhesions. However, a comprehensive synthesis centered on the roles of RCD in endometrial diseases is still lacking. This review systematically summarizes the roles of various RCD pathways—apoptosis, autophagy, ferroptosis, pyroptosis, and cuproptosis—in endometrial diseases, emphasizing their interactions with hormonal signaling, molecular mechanisms in different endometrial cells, and cell–cell communication. It also evaluates therapeutic strategies targeting RCD, offering insights into potential interventions for diseases, such as endometriosis, intrauterine adhesion, and embryo implantation failure.</p>

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Regulated cell death in endometrial diseases: from molecular mechanisms to targeted therapies

  • 期刊论文

  • 发表日期：

    2025年9月22日

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  • Duo Zi,
  • Jing Sun,
  • Na Zuo,
  • Tingting Li,
  • Junzhi Liang,
  • Jia Hu,
  • Zhijing Na,
  • Hao Zhang,
  • Lixia He,
  • Da Li

摘要

Regulated cell death (RCD) is a fundamental biological process essential for tissue homeostasis and disease regulation. Increasing evidence has demonstrated that RCD plays a pivotal role in the pathogenesis of uterine endometrial diseases, including endometriosis, abnormal decidualization, endometrial receptivity defects, and intrauterine adhesions. However, a comprehensive synthesis centered on the roles of RCD in endometrial diseases is still lacking. This review systematically summarizes the roles of various RCD pathways—apoptosis, autophagy, ferroptosis, pyroptosis, and cuproptosis—in endometrial diseases, emphasizing their interactions with hormonal signaling, molecular mechanisms in different endometrial cells, and cell–cell communication. It also evaluates therapeutic strategies targeting RCD, offering insights into potential interventions for diseases, such as endometriosis, intrauterine adhesion, and embryo implantation failure.