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<p>While <i>Micrurus</i> venoms are primarily recognized for inducing neurotoxic effects, experimental findings have also documented additional manifestations such as local effects such as edema, myotoxicity, and inflammation. However, limited information is available regarding the impact of <i>Micrurus</i> venom on leukocyte functions. In this study, we investigated the in vivo effects of <i>Micrurus lemniscatus</i> venom (ML venom) on peritoneal leukocyte functions. Intraperitoneal (i.p.) injection of ML venom stimulated leukocyte migration, particularly at lower doses, with predominance of mononuclear cells. Both doses also triggered the release of cytokines (TNF-α, IL-1β, and IL-6) three hours after injection. Additionally, ML venom elicited the production of reactive oxygen species (ROS) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), as well as enhanced phagocytosis, along with the release of dsDNA and lipid droplets by these cells. This study represents the first demonstration of peritoneal leukocyte activation by <i>Micrurus lemniscatus</i> venom.</p>

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Micrurus lemniscatus venom stimulates leukocyte functions in vivo

  • 期刊论文

  • 发表日期：

    2025年2月13日

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  • Luciana Lyra Casais-e-Silva,
  • Larissa Faustina Cruz,
  • Valdison P. dos Reis,
  • Mauro V. Paloschi,
  • Catarina Teixeira,
  • Juliana P. Zuliani,
  • Sulamita da Silva Setubal

摘要

While Micrurus venoms are primarily recognized for inducing neurotoxic effects, experimental findings have also documented additional manifestations such as local effects such as edema, myotoxicity, and inflammation. However, limited information is available regarding the impact of Micrurus venom on leukocyte functions. In this study, we investigated the in vivo effects of Micrurus lemniscatus venom (ML venom) on peritoneal leukocyte functions. Intraperitoneal (i.p.) injection of ML venom stimulated leukocyte migration, particularly at lower doses, with predominance of mononuclear cells. Both doses also triggered the release of cytokines (TNF-α, IL-1β, and IL-6) three hours after injection. Additionally, ML venom elicited the production of reactive oxygen species (ROS) and hydrogen peroxide (H2O2), as well as enhanced phagocytosis, along with the release of dsDNA and lipid droplets by these cells. This study represents the first demonstration of peritoneal leukocyte activation by Micrurus lemniscatus venom.