Scholarlink

<p>Quorum sensing (QS), a key bacterial cell-to-cell signaling process, regulates group behaviors including biofilm formation, virulence factor production, and antibiotic resistance among the ESKAPE pathogens especially in <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i>. This review presents a comprehensive comparative evaluation of QS systems, with emphasis on the Las, Rhl, and PQS systems in <i>P. aeruginosa</i> and AI-1, AI-2, and SdiA cascades in <i>K. pneumoniae</i>. We examine the varied and interconnected roles of QS-regulated genes in modulating biofilm development, virulence determinants, and antibiotic resistance through the upregulation of efflux pump expression in these pathogens. Through the identification of similarities and differences between QS systems and their impact on resistance, the review aims to guide future research and the development of novel therapeutic strategies to fight infections caused by <i>P. aeruginosa</i> and <i>K. pneumoniae</i>. Additionally, understanding QS networks may help guiding combination therapies and inform strategies to prevent the emergence of antimicrobial resistance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative analysis of quorum sensing mechanisms in Pseudomonas aeruginosa and Klebsiella pneumoniae: implications for antibiotic resistance

  • 期刊论文

  • 发表日期：

    2025年12月15日

查看全文
  • Bhavan Vishal Venkatesan,
  • Anand Anbarasu,
  • Rajiniraja Muniyan

摘要

Quorum sensing (QS), a key bacterial cell-to-cell signaling process, regulates group behaviors including biofilm formation, virulence factor production, and antibiotic resistance among the ESKAPE pathogens especially in Pseudomonas aeruginosa and Klebsiella pneumoniae. This review presents a comprehensive comparative evaluation of QS systems, with emphasis on the Las, Rhl, and PQS systems in P. aeruginosa and AI-1, AI-2, and SdiA cascades in K. pneumoniae. We examine the varied and interconnected roles of QS-regulated genes in modulating biofilm development, virulence determinants, and antibiotic resistance through the upregulation of efflux pump expression in these pathogens. Through the identification of similarities and differences between QS systems and their impact on resistance, the review aims to guide future research and the development of novel therapeutic strategies to fight infections caused by P. aeruginosa and K. pneumoniae. Additionally, understanding QS networks may help guiding combination therapies and inform strategies to prevent the emergence of antimicrobial resistance.