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<p>Humans and poultry are both susceptible to hyperuricemia, due to mutations in the uric acid oxidase gene. Chinese medicinal-edible plants have been extensively utilized in the management of hyperuricemia. Extracts of medicinal-edible plants have been extensively studied in the treatment of hyperuricemia. However, the endophytic bacteria in these medicinal-edible plants have been rarely studied. In the present study, four strains of Bacillus with uricolytic activity were isolated and identified from four medicinal-edible plants. The strain with the highest uricolytic activity comes from sunflowers and is a novel species named XRK-1. The 16&#xa0;S rRNA sequence of XRK-1 shares 96.3% homology with the most similar <i>Ornithinibacillus salinisoli</i> LCB256 (14-AUG-2023). After evaluating the safety and the tolerance of acid and choline in vitro, XRK-1 with 10<sup>7</sup> CFU/kg was added to goose feed daily for 3 weeks. The results of the preliminary animal trials showed that the serum uric acid levels of 1-day-old and 21-day-old geese fed with XRK-1 decreased by 32.5% and 15.0% respectively compared to the control group. These findings suggest that endophytes with uricolytic activity in medicinal-edible plants play a certain role in the management of hyperuricemia in plant dietary therapy.</p>

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Uricolytic Bacillus from medicinal-edible plants ameliorates hyperuricemia in geese

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Chao Wei,
  • Junxuan Cao,
  • Boyang Hu,
  • Zetao Du,
  • Hongyu Zhang,
  • Yujie Dai,
  • Ao Peng,
  • Yanyang Liao,
  • Zhaoxia Zou,
  • Chunliang Xie,
  • Jinjun Chen

摘要

Humans and poultry are both susceptible to hyperuricemia, due to mutations in the uric acid oxidase gene. Chinese medicinal-edible plants have been extensively utilized in the management of hyperuricemia. Extracts of medicinal-edible plants have been extensively studied in the treatment of hyperuricemia. However, the endophytic bacteria in these medicinal-edible plants have been rarely studied. In the present study, four strains of Bacillus with uricolytic activity were isolated and identified from four medicinal-edible plants. The strain with the highest uricolytic activity comes from sunflowers and is a novel species named XRK-1. The 16 S rRNA sequence of XRK-1 shares 96.3% homology with the most similar Ornithinibacillus salinisoli LCB256 (14-AUG-2023). After evaluating the safety and the tolerance of acid and choline in vitro, XRK-1 with 107 CFU/kg was added to goose feed daily for 3 weeks. The results of the preliminary animal trials showed that the serum uric acid levels of 1-day-old and 21-day-old geese fed with XRK-1 decreased by 32.5% and 15.0% respectively compared to the control group. These findings suggest that endophytes with uricolytic activity in medicinal-edible plants play a certain role in the management of hyperuricemia in plant dietary therapy.