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<p><i>Salmonella</i> is an important foodborne pathogen, and its quinolone resistance poses a considerable threat to public health. This review comprehensively analyzes various quinolone resistance mechanisms of <i>Salmonella</i>, including mutations in genes encoding drug targets, export of quinolones by efflux pump systems, decrease in <i>Salmonella</i> cell permeability, and the formation of special physiological states. The <i>gyrA</i> and <i>parC</i> are two important genes encoding the drug targets of quinolones, and their genetic mutations result in the drug targets being unable to be recognized by quinolones. Many efflux pumps, such as AcrAB, MdtABC, MdsABC, EmrAB, etc., transport quinolones out of <i>Salmonella</i> cells. A reduction in the expression of some porins decreases quinolone permeability, further aggravating drug resistance. In addition, special physiological states of <i>Salmonella</i>, such as a low metabolic state, biofilms, and quorum sensing, significantly increase quinolone resistance of <i>Salmonella</i>. The development of quinolone resistance in <i>Salmonella</i> is a complex process involving the synergistic effects of multiple mechanisms.</p>

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The molecular mechanisms of quinolone resistance in Salmonella: a review

  • 期刊论文

  • 发表日期：

    2025年8月19日

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  • Jing Wang,
  • Zichun Sang,
  • Yifei Zhao,
  • Qiwen Wang,
  • Xiaowen Hu,
  • Ting Ni,
  • Chang Liu,
  • Huobing Liao,
  • Heyu Zhang,
  • Xingyu Xia

摘要

Salmonella is an important foodborne pathogen, and its quinolone resistance poses a considerable threat to public health. This review comprehensively analyzes various quinolone resistance mechanisms of Salmonella, including mutations in genes encoding drug targets, export of quinolones by efflux pump systems, decrease in Salmonella cell permeability, and the formation of special physiological states. The gyrA and parC are two important genes encoding the drug targets of quinolones, and their genetic mutations result in the drug targets being unable to be recognized by quinolones. Many efflux pumps, such as AcrAB, MdtABC, MdsABC, EmrAB, etc., transport quinolones out of Salmonella cells. A reduction in the expression of some porins decreases quinolone permeability, further aggravating drug resistance. In addition, special physiological states of Salmonella, such as a low metabolic state, biofilms, and quorum sensing, significantly increase quinolone resistance of Salmonella. The development of quinolone resistance in Salmonella is a complex process involving the synergistic effects of multiple mechanisms.