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Summary <p>We examined the multimorbidity patterns among fragility fracture patients in China and the US. Except for female fracture patients in US, hyperlipidemia was the most prevalent comorbidity among fracture patients in China and the US. US fracture patients demonstrated a similar complex comorbidity network to non-fracture individuals.</p> Purpose <p>To examine the multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.</p> Methods <p>We extracted inpatient electronic medical records at the First Affiliated Hospital of Jinzhou Medical University, China between 2018 and 2023, and data from the National Health and Nutrition Examination Survey (NHANES) 1999–2020. Fragility fracture patients aged ≥ 50&#xa0;years were identified. In the NHANES, we matched each fracture patient with a non-fracture individual by age (&lt; 1&#xa0;year), sex and survey cycle. We identified 28 and 19 chronic diseases in the Chinese and NHANES databases, respectively. Average degree was used to characterize the complexity of comorbidity network.</p> Results <p>A total of 2086 Chinese fracture patients, 1227 US fracture and 1227 non-fracture individuals were included (73% females). The most prevalent comorbidity among Chinese fracture patients was hyperlipidemia (male: 63.3%; female: 65.2%). In US fracture patients, the most prevalent comorbidity was hyperlipidemia (67.3%) in males and osteoporosis (78.3%) in females. The most prevalent disease pair was osteoporosis and hyperlipidemia among US fracture patients (male: 40.8%; female: 61.4%), and hypertension and hyperlipidemia among Chinese fracture patients (male: 26.6%; female: 29.4%). The multimorbidity pattern of US fracture patients was similar to that of non-fracture individuals (average degree: 7.82 vs. 7.59 in males; 7.94 vs. 7.44 in females).</p> Conclusion <p>Except among female fracture patients in the US, hyperlipidemia was the most prevalent comorbidity among Chinese and US fragility fracture patients. US fracture patients demonstrated a similar complex comorbidity network to non-fracture individuals.</p>

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Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US

  • 期刊论文

  • 发表日期：

    2026年6月25日

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  • Qi Meng,
  • Yi Wang,
  • Linghua Yang,
  • Ann M. Vuong,
  • William D. Leslie,
  • Lisa M. Lix,
  • Sumbal Javaid,
  • Bo Kan,
  • Shuman Yang

摘要

Summary

We examined the multimorbidity patterns among fragility fracture patients in China and the US. Except for female fracture patients in US, hyperlipidemia was the most prevalent comorbidity among fracture patients in China and the US. US fracture patients demonstrated a similar complex comorbidity network to non-fracture individuals.

Purpose

To examine the multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

Methods

We extracted inpatient electronic medical records at the First Affiliated Hospital of Jinzhou Medical University, China between 2018 and 2023, and data from the National Health and Nutrition Examination Survey (NHANES) 1999–2020. Fragility fracture patients aged ≥ 50 years were identified. In the NHANES, we matched each fracture patient with a non-fracture individual by age (< 1 year), sex and survey cycle. We identified 28 and 19 chronic diseases in the Chinese and NHANES databases, respectively. Average degree was used to characterize the complexity of comorbidity network.

Results

A total of 2086 Chinese fracture patients, 1227 US fracture and 1227 non-fracture individuals were included (73% females). The most prevalent comorbidity among Chinese fracture patients was hyperlipidemia (male: 63.3%; female: 65.2%). In US fracture patients, the most prevalent comorbidity was hyperlipidemia (67.3%) in males and osteoporosis (78.3%) in females. The most prevalent disease pair was osteoporosis and hyperlipidemia among US fracture patients (male: 40.8%; female: 61.4%), and hypertension and hyperlipidemia among Chinese fracture patients (male: 26.6%; female: 29.4%). The multimorbidity pattern of US fracture patients was similar to that of non-fracture individuals (average degree: 7.82 vs. 7.59 in males; 7.94 vs. 7.44 in females).

Conclusion

Except among female fracture patients in the US, hyperlipidemia was the most prevalent comorbidity among Chinese and US fragility fracture patients. US fracture patients demonstrated a similar complex comorbidity network to non-fracture individuals.