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<p>The association between circulating soluble klotho (s-klotho) levels and hip fracture risk is uncertain. We assessed this relationship in 4428 older adults followed for a median of 11.8&#xa0;years, during which 602 hip fractures occurred. In the overall cohort, s-klotho levels were marginally but not significantly associated with hip fracture risk (hazard ratio (HR) per standard deviation increase, 0.92; 95% CI, 0.83–1.01; <i>p</i> = 0.075). In exploratory analyses, participants in the highest 5% of s-klotho levels (&gt; 1615.2 pg/ml) exhibited a substantially lower risk of hip fracture (adjusted HR, 0.48; 95% CI, 0.27–0.85; <i>p</i> = 0.01), suggesting a threshold effect in which only very high s-klotho concentrations are associated with reduced risk. This finding may help explain inconsistencies in prior studies.</p>

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Soluble klotho levels and hip fracture risk in the elderly

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月1日

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  • Joshua I. Barzilay,
  • Petra Bůžková,
  • Howard A. Fink,
  • Jane A. Cauley,
  • John A. Robbins,
  • Rachel Elam,
  • Laura Carbone,
  • Kenneth J. Mukamal

摘要

The association between circulating soluble klotho (s-klotho) levels and hip fracture risk is uncertain. We assessed this relationship in 4428 older adults followed for a median of 11.8 years, during which 602 hip fractures occurred. In the overall cohort, s-klotho levels were marginally but not significantly associated with hip fracture risk (hazard ratio (HR) per standard deviation increase, 0.92; 95% CI, 0.83–1.01; p = 0.075). In exploratory analyses, participants in the highest 5% of s-klotho levels (> 1615.2 pg/ml) exhibited a substantially lower risk of hip fracture (adjusted HR, 0.48; 95% CI, 0.27–0.85; p = 0.01), suggesting a threshold effect in which only very high s-klotho concentrations are associated with reduced risk. This finding may help explain inconsistencies in prior studies.