<p>The effects of temperature on cavitation behavior have been examined in non-biological engineering applications, e.g., water purification, propeller degradation. However, there is a lack of detailed results on how temperature may affect shock-induced cavitation modeling for biological systems. In particular, it is essential to establish if experiments of biological systems (and surrogate biological systems) conducted at room temperature are accurate representations of cavitation at body temperatures. Additionally, many existing works on biological cavitation utilize distilled water. While distilled water is purified, it is not guaranteed to be free from all ions and is still slightly conductive. Since the impact of ion concentration on cavitation behavior has also yet to be quantified, it is preferable to utilize deionized (DI) water for such experiments. As a result, the present study examines the effect of temperature on shock-induced cavitation using a novel shock tube model to visually record the cavitation events in deionized water. Results show a statistically significant relationship between temperature and cavitation bubble number. Although deionized water was used in this study, the results highlight the need to incorporate temperature into future simulations and experiments involving biological fluids in shock wave environments.</p>