Scholarlink

Introduction and Hypothesis <p>A subset of women with stress urinary incontinence (SUI) exhibit atypical features that may suggest hidden storage dysfunction or bladder overactivity. As urodynamic studies (UDS) are invasive and not always accessible, this study was aimed at examining whether a short solifenacin trial could improve symptoms and help treat women with SUI who present atypical leakage patterns.</p> Methods <p>Fifty women (39–60&#xa0;years old) suffering from clinically diagnosed SUI with atypical features were treated with solifenacin 5&#xa0;mg daily over the course of 4 weeks. The International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form (ICIQ-UI-SF) and the Overactive Bladder Symptom Score (OABSS) were used to measure changes in symptoms. The primary outcome measures were changes in total scores and achievement of clinically meaningful improvement (≥ 4-point reduction in ICIQ-UI-SF; ≥ 3-point reduction in OABSS).</p> Results <p>The mean age of the participants was 51.9 ± 4.9&#xa0;years. Mean ICIQ-UI-SF scores decreased from 15.4 ± 2.7 to 6.7 ± 2.4 (<i>p</i> &lt; 0.001; Cohen’s <i>d</i> = 2.4), and OABSS scores from 5.4 ± 2.2 to 2.0 ± 1.3 (<i>p</i> &lt; 0.001;&#xa0;Cohen's <i>d</i> = 1.8). Clinically significant improvement was observed in 92% (according to ICIQ-UI-SF) and 80% (according to OABSS) of patients (<i>p</i> &lt; 0.001).</p> Conclusions <p>Solifenacin therapy resulted in statistically and clinically significant improvement of UI and storage symptoms among women with SUI exhibiting atypical features and managed without baseline UDS. These results suggest that a pharmacological trial may be a practical, non-invasive first-line approach for this SUI phenotype, may be consistent with a cough-induced detrusor overactivity-like mechanism, but cannot confirm it in the absence of urodynamic study.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pharmacological Management of Stress Urinary Incontinence with Atypical Leakage Features, Symptom Response to Short-term Solifenacin Trial

  • 期刊论文

  • 发表日期：

    2026年4月7日

查看全文
  • Mansooreh Yaraghi,
  • Amin Mohammadamini,
  • Mobina Taghva Nakhjiri

摘要

Introduction and Hypothesis

A subset of women with stress urinary incontinence (SUI) exhibit atypical features that may suggest hidden storage dysfunction or bladder overactivity. As urodynamic studies (UDS) are invasive and not always accessible, this study was aimed at examining whether a short solifenacin trial could improve symptoms and help treat women with SUI who present atypical leakage patterns.

Methods

Fifty women (39–60 years old) suffering from clinically diagnosed SUI with atypical features were treated with solifenacin 5 mg daily over the course of 4 weeks. The International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form (ICIQ-UI-SF) and the Overactive Bladder Symptom Score (OABSS) were used to measure changes in symptoms. The primary outcome measures were changes in total scores and achievement of clinically meaningful improvement (≥ 4-point reduction in ICIQ-UI-SF; ≥ 3-point reduction in OABSS).

Results

The mean age of the participants was 51.9 ± 4.9 years. Mean ICIQ-UI-SF scores decreased from 15.4 ± 2.7 to 6.7 ± 2.4 (p < 0.001; Cohen’s d = 2.4), and OABSS scores from 5.4 ± 2.2 to 2.0 ± 1.3 (p < 0.001; Cohen's d = 1.8). Clinically significant improvement was observed in 92% (according to ICIQ-UI-SF) and 80% (according to OABSS) of patients (p < 0.001).

Conclusions

Solifenacin therapy resulted in statistically and clinically significant improvement of UI and storage symptoms among women with SUI exhibiting atypical features and managed without baseline UDS. These results suggest that a pharmacological trial may be a practical, non-invasive first-line approach for this SUI phenotype, may be consistent with a cough-induced detrusor overactivity-like mechanism, but cannot confirm it in the absence of urodynamic study.