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Introduction and Hypothesis <p>This study aimed to evaluate the effectiveness of platelet-rich plasma (PRP) combined with fractional CO<sub>2</sub> laser therapy in women diagnosed with mild or moderate stress urinary incontinence (SUI).</p> Methods <p>In this single-center, single-blinded, randomized controlled trial, 69 women diagnosed with mild or moderate SUI were randomly assigned to receive fractional CO<sub>2</sub> laser therapy, PRP injections, or a combination of both treatments (<i>n</i> = 23 per group). Each participant underwent three treatment sessions at 30-day intervals. Outcomes were assessed using the International Consultation on Incontinence Questionnaire–Short Form (ICI-Q-SF), the Incontinence Quality of Life (I-QOL) questionnaire, and a 1-h pad test at baseline and at 1, 3, and 6&#xa0;months post-treatment. Generalized estimating equations (GEE) were used to analyze repeated measures across groups.</p> Results <p>No statistically significant differences in baseline characteristics were observed among the groups (<i>P</i> &gt; 0.05). All groups demonstrated significant post-treatment improvements in ICI-Q-SF scores, I-QOL scores, and 1-h pad weights (<i>P</i> &lt; 0.05). Compared to the fractional CO<sub>2</sub> laser group, the PRP group showed no significant advantage, whereas the combined group exhibited significantly greater improvements at all time points: greater reductions in ICI-Q-SF scores (β = −1.09, −1.30, −1.39; all <i>P</i> &lt; 0.001), higher I-QOL scores (β = 4.39, 4.61, 5.04; all <i>P</i> &lt; 0.001), and greater decreases in pad weights (β = −1.22, −1.48, −1.78; all <i>P</i> &lt; 0.05).</p> Conclusions <p>Combined PRP and fractional CO<sub>2</sub> laser therapy significantly improves urinary incontinence symptoms and quality of life compared to either treatment alone, offering a potentially more effective therapeutic option for women diagnosed with mild or moderate SUI.</p>

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A Randomized Controlled Trial of Platelet-Rich Plasma Combined with Fractional CO2 Laser Therapy for Mild and Moderate Stress Urinary Incontinence in Women

  • 期刊论文

  • 发表日期：

    2025年9月8日

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  • Mingjing Lu,
  • Weijiao Liu,
  • Yuchan Wu,
  • Kaixian Deng

摘要

Introduction and Hypothesis

This study aimed to evaluate the effectiveness of platelet-rich plasma (PRP) combined with fractional CO2 laser therapy in women diagnosed with mild or moderate stress urinary incontinence (SUI).

Methods

In this single-center, single-blinded, randomized controlled trial, 69 women diagnosed with mild or moderate SUI were randomly assigned to receive fractional CO2 laser therapy, PRP injections, or a combination of both treatments (n = 23 per group). Each participant underwent three treatment sessions at 30-day intervals. Outcomes were assessed using the International Consultation on Incontinence Questionnaire–Short Form (ICI-Q-SF), the Incontinence Quality of Life (I-QOL) questionnaire, and a 1-h pad test at baseline and at 1, 3, and 6 months post-treatment. Generalized estimating equations (GEE) were used to analyze repeated measures across groups.

Results

No statistically significant differences in baseline characteristics were observed among the groups (P > 0.05). All groups demonstrated significant post-treatment improvements in ICI-Q-SF scores, I-QOL scores, and 1-h pad weights (P < 0.05). Compared to the fractional CO2 laser group, the PRP group showed no significant advantage, whereas the combined group exhibited significantly greater improvements at all time points: greater reductions in ICI-Q-SF scores (β = −1.09, −1.30, −1.39; all P < 0.001), higher I-QOL scores (β = 4.39, 4.61, 5.04; all P < 0.001), and greater decreases in pad weights (β = −1.22, −1.48, −1.78; all P < 0.05).

Conclusions

Combined PRP and fractional CO2 laser therapy significantly improves urinary incontinence symptoms and quality of life compared to either treatment alone, offering a potentially more effective therapeutic option for women diagnosed with mild or moderate SUI.