Introduction and Hypothesis <p>Neovagina creation is an essential area of research in gynecological and reconstructive surgery, addressing congenital conditions like Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome and transgender health needs. This study aims to provide a comprehensive bibliometric analysis of global research trends, influential contributors, and thematic developments in this evolving field.</p> Methods <p>Data were retrieved from the Web of Science Core Collection, encompassing 357 publications from 56 countries. Bibliometric tools, including VOSviewer, were used to analyze publication trends, author and institutional contributions, and keyword co-occurrences. The study also visualized global collaborations and thematic patterns.</p> Results <p>The United States and Italy emerged as the leading contributors, reflecting their advanced research infrastructure and resources. Frequently occurring keywords, including “neovagina,” “vaginal agenesis,” and “Mayer–Rokitansky–Küster–Hauser syndrome,” highlighted the focus on congenital conditions and surgical reconstruction. Time-series analysis revealed increasing attention to uterus transplantation and transgender health since 2018. However, the study identified limited contributions from low-resource regions and insufficient international collaboration.</p> Conclusions <p>This analysis highlights the evolving landscape of neovagina creation research, driven by multidisciplinary approaches and thematic diversity. While significant progress has been made, global disparities and research gaps remain. Addressing these issues through international collaborations and equitable research initiatives is critical to advancing clinical practices and improving outcomes for all patients requiring neovagina creation.</p>