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<p>The need for tissue-engineered mats for soft tissue repair regeneration is rising due to increasing numbers of traumatic injuries. In this study, novel, biocompatible electrospun mat based on polyvinyl alcohol (PVA) and alginate dialdehyde-gelatin (ADA-GEL) loaded with Lawsone was proposed to serve the purpose quite efficiently with the cost-effective and reproducible electrospinning technique. Developed mat was porous and can hold moisture up to ~ 250% in 24&#xa0;h, which hydrates the wound site as required, particularly in burnt patients. Additionally, the porous nature revealed via scanning electron microscopy also aids in loading drug of choice (i.e., Lawsone) with precise control over its release, which is ~ 65% in 7 days. Despite the porous nature, the degradation of the crosslinked network (confirmed via FTIR) also helps in the leaching of entrapped Lawsone molecules. The interconnected porous network entraps Lawsone molecules until degradation, offering prolonged antimicrobial efficacy, assessed via disc diffusion assay. The Lawsone loaded mats offered a broad-spectrum antibacterial effect, i.e., 4&#xa0;mm against <i>Escherichia coli</i> (<i>E. coli</i>) and 6&#xa0;mm against <i>Staphylococcus aureus</i> (<i>S. aureus</i>). Additionally, the viability of developed PVA/ADA-GEL/Lawsone mats towards fibroblast cells pose the potential to be further investigated in wound healing applications.</p>

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Lawsone-loaded PVA/alginate dialdehyde-gelatin electrospun fibers for wound healing: development and characterization

  • 期刊论文

  • 发表日期：

    2025年11月20日

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  • Aqsa Aizaz,
  • Muhammad Haseeb Nawaz,
  • Akbar Niaz,
  • Mohammad Faseeulla,
  • Muhammad Mudassir Ahmad Alwi,
  • Muhammad Atiq Ur Rehman

摘要

The need for tissue-engineered mats for soft tissue repair regeneration is rising due to increasing numbers of traumatic injuries. In this study, novel, biocompatible electrospun mat based on polyvinyl alcohol (PVA) and alginate dialdehyde-gelatin (ADA-GEL) loaded with Lawsone was proposed to serve the purpose quite efficiently with the cost-effective and reproducible electrospinning technique. Developed mat was porous and can hold moisture up to ~ 250% in 24 h, which hydrates the wound site as required, particularly in burnt patients. Additionally, the porous nature revealed via scanning electron microscopy also aids in loading drug of choice (i.e., Lawsone) with precise control over its release, which is ~ 65% in 7 days. Despite the porous nature, the degradation of the crosslinked network (confirmed via FTIR) also helps in the leaching of entrapped Lawsone molecules. The interconnected porous network entraps Lawsone molecules until degradation, offering prolonged antimicrobial efficacy, assessed via disc diffusion assay. The Lawsone loaded mats offered a broad-spectrum antibacterial effect, i.e., 4 mm against Escherichia coli (E. coli) and 6 mm against Staphylococcus aureus (S. aureus). Additionally, the viability of developed PVA/ADA-GEL/Lawsone mats towards fibroblast cells pose the potential to be further investigated in wound healing applications.