<p>Industry 4.0 brings smartness to manufacturing systems through Cyber-Physical Systems (CPS), Digital Twins (DT), and the Internet of Things. Going a step further, Industry 5.0 seeks to achieve these modern manufacturing industry goals by integrating the precision of robots/cobots with human creativity by establishing human-centered CPS. Hence, it is crucial to have a good understanding of key technological adjustments and how they are being incorporated for sustaining human-centricity, resilience, and reconfigurability in CPS-based workcells. This systematic search and review addresses this central research question. The review was based on carefully established systematic search and elimination/inclusion criteria. After a gradual filtering process as elaborated in this paper, 88 related articles were deeply analyzed to arrive at the conclusions. The significance of this review is that it analyzes research works based on CPS platforms to identify how the technicalities at each level of the CPS establishment can support sustaining human-centered applications. It was identified that novel approaches are obtained by adjusting the decision-making algorithms of the CPS. An overuse of virtual reality methods was noticed. There is a requirement for improved and reliable biosensing applications. Parallel improvements in other industries such as interoperability and cyber-security can provide better support for the changes in the focused industry. These findings will be useful for future research trends in the manufacturing industry.</p>