<p>The thermal management of batteries is one of the key challenges of electric mobility in the automotive sector. Lithium-Ion batteries as well as other common battery types operate best in a certain temperature range, as the energy capacity drops outside of the range. Furthermore, aging effects can occur, reducing the battery lifetime. Therefore, a thermal management system is part of the battery pack. Battery cooling plates with integrated channel structure that are passed by a fluid for indirect liquid cooling by forced convection are a common realization of such systems. One of the most innovative and promising technologies for the efficient production of such plates is Rollbonding. The technology is characterized by competitive cost, great design freedom, and flexibility, as it enables the production of channel patterns without the need for a dedicated forming tool for every design. Designing battery cooling plates is challenging because conflicting thermal and hydraulic targets must be considered while ensuring manufacturability. Topology optimization is a well-known technology that can help designing optimal structures. One of the major challenges of topology optimization is the generation of designs that are feasible for the dedicated manufacturing technology. This paper addresses this issue by presenting an optimization strategy that considers the relevant manufacturing constraints based on machine learning models. These models are trained based on simulation data such that parameters like maximum material thinning and minimum channel height can be predicted and consequently considered within the optimization. Furthermore, a 3D parametrization strategy is presented that enables the representation of realistic 3D channel shapes as they result from the manufacturing process. This way, the hydraulic and thermal performance can be predicted with better accuracy compared to classical 2D methods.</p>