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<p>Extracorporeal life support (ECLS), including venovenous extracorporeal membrane oxygenation (VV-ECMO) and extracorporeal carbon dioxide removal (ECCO₂R), is an established treatment for selected patients with acute respiratory distress syndrome (ARDS). In this review, on the 60th anniversary of ARDS, we review the evolution of ECLS as a support strategy in ARDS, the evidence surrounding its efficacy, factors associated with prognosis, management of patients on ECLS, associated complications, and long-term outcomes among survivors. We also highlight existing areas of uncertainty, and ongoing clinical research that will define the next decade and beyond of ECLS for ARDS.</p> Visual abstract <p></p>

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60 years of ARDS and the evolution of extracorporeal lung support – from ECMO to ECCO2R

  • 期刊论文

  • 发表日期：

    2026年7月7日

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  • Shannon M. Fernando,
  • Daniel Brodie,
  • Arthur S. Slutsky,
  • Darryl Abrams,
  • Cara Agerstrand,
  • Luigi Camporota,
  • Eddy Fan,
  • Niall D. Ferguson,
  • Carol L. Hodgson,
  • Catherine L. Hough,
  • Gennaro Martucci,
  • Laveena Munshi,
  • Marlies Ostermann,
  • Brijesh V. Patel,
  • Matthieu Schmidt,
  • Kiran Shekar,
  • Alexander Supady,
  • Alain Combes

摘要

Extracorporeal life support (ECLS), including venovenous extracorporeal membrane oxygenation (VV-ECMO) and extracorporeal carbon dioxide removal (ECCO₂R), is an established treatment for selected patients with acute respiratory distress syndrome (ARDS). In this review, on the 60th anniversary of ARDS, we review the evolution of ECLS as a support strategy in ARDS, the evidence surrounding its efficacy, factors associated with prognosis, management of patients on ECLS, associated complications, and long-term outcomes among survivors. We also highlight existing areas of uncertainty, and ongoing clinical research that will define the next decade and beyond of ECLS for ARDS.

Visual abstract