Consistency of data reporting in fluid responsiveness studies in the critically ill setting: the CODEFIRE consensus from the Cardiovascular Dynamic section of the European Society of Intensive Care Medicine

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发表日期：

2024年3月14日

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Antonio Messina,
Michelle S. Chew,
Daniele Poole,
Lorenzo Calabrò,
Daniel De Backer,
Katia Donadello,
Glenn Hernandez,
Olfa Hamzaoui,
Mathieu Jozwiak,
Christopher Lai,
Manu L. N. G. Malbrain,
Jihad Mallat,
Sheyla Nainan Myatra,
Laurent Muller,
Gustavo Ospina-Tascon,
Michael R. Pinsky,
Sebastian Preau,
Bernd Saugel,
Jean-Louis Teboul,
Maurizio Cecconi,
Xavier Monnet

摘要

Purpose

To provide consensus recommendations regarding hemodynamic data reporting in studies investigating fluid responsiveness and fluid challenge (FC) use in the intensive care unit (ICU).

Methods

The Executive Committee of the European Society of Intensive Care Medicine (ESICM) commissioned and supervised the project. A panel of 18 international experts and a methodologist identified main domains and items from a systematic literature, plus 2 ancillary domains. A three-step Delphi process based on an iterative approach was used to obtain the final consensus. In the Delphi 1 and 2, the items were selected with strong (≥ 80% of votes) or week agreement (70–80% of votes), while the Delphi 3 generated recommended (≥ 90% of votes) or suggested (80–90% of votes) items (RI and SI, respectively).

Results

We identified 5 main domains initially including 117 items and the consensus finally resulted in 52 recommendations or suggestions: 18 RIs and 2 SIs statements were obtained for the domain “ICU admission”, 11 RIs and 1 SI for the domain “mechanical ventilation”, 5 RIs for the domain “reason for giving a FC”, 8 RIs for the domain pre- and post-FC “hemodynamic data”, and 7 RIs for the domain “pre-FC infused drugs”. We had no consensus on the use of echocardiography, strong agreement regarding the volume (4 ml/kg) and the reference variable (cardiac output), while weak on administration rate (within 10 min) of FC in this setting.

Conclusion

This consensus found 5 main domains and provided 52 recommendations for data reporting in studies investigating fluid responsiveness in ICU patients.