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Background <p>Osteoeporotic vertebral fractures are one of the most common injuries in the elderly, with a&#xa0;prevalence of 10&#xa0;to 15% in the population over 50&#xa0;years of age. This type of fracture can be treated with minimally invasive surgery using kyphoplasty. The aim of this analysis is to show the advantages and disadvantages of treatment with kyphoplasty and to weigh up the different ways of performing this operation.</p> Methods <p>The systematic literature search included randomized controlled trials and clinical studies in the period from 01/09/2018–31/08/2024. The updated 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used for evaluation.</p> Results <p>A&#xa0;total of 16&#xa0;studies from 4347 datasets were included. The most relevant outcome indices showed that the sole choice of surgical side (surgery from the symptom-dominant side) positively influences the VAS. In addition, the unilateral approach is recommended, as this is associated with a&#xa0;shorter operation time, as well as reduced cement volume and radiation exposure. Furthermore, bone density, different scores and certain biomarkers, such as NMID, beta-CTX and P1NP, can be positively influenced by the intravenous administration of zoledronic acid. PMMA bone cement loaded with gentamicin should be used as cement. Finally, drug treatment for osteoporosis and physical therapy are essential for postoperative recovery.</p> Conclusion <p>Surgical treatment of an osteoporotic vertebral fracture by means of kyphoplasty leads to improved results, even with the inclusion of additional therapies.</p>

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Literaturrecherche zur Kyphoplastie als Behandlung osteoporotischer Frakturen an der Wirbelsäule

  • 期刊论文

  • 发表日期：

    2025年4月4日

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  • Celine Zöllinger,
  • Franz Landauer,
  • Klemens Trieb

摘要

Background

Osteoeporotic vertebral fractures are one of the most common injuries in the elderly, with a prevalence of 10 to 15% in the population over 50 years of age. This type of fracture can be treated with minimally invasive surgery using kyphoplasty. The aim of this analysis is to show the advantages and disadvantages of treatment with kyphoplasty and to weigh up the different ways of performing this operation.

Methods

The systematic literature search included randomized controlled trials and clinical studies in the period from 01/09/2018–31/08/2024. The updated 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used for evaluation.

Results

A total of 16 studies from 4347 datasets were included. The most relevant outcome indices showed that the sole choice of surgical side (surgery from the symptom-dominant side) positively influences the VAS. In addition, the unilateral approach is recommended, as this is associated with a shorter operation time, as well as reduced cement volume and radiation exposure. Furthermore, bone density, different scores and certain biomarkers, such as NMID, beta-CTX and P1NP, can be positively influenced by the intravenous administration of zoledronic acid. PMMA bone cement loaded with gentamicin should be used as cement. Finally, drug treatment for osteoporosis and physical therapy are essential for postoperative recovery.

Conclusion

Surgical treatment of an osteoporotic vertebral fracture by means of kyphoplasty leads to improved results, even with the inclusion of additional therapies.