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<p>Cervical cancer remains the fourth most common malignancy among women worldwide, frequently affecting patients of reproductive age. In early stages (Fédération Internationale de Gynécologie et d’Obstétrique [FIGO] IA–IB1), conization, simple, or radical trachelectomy can preserve the uterus and fertility. Sentinel lymph node mapping has become the minimally invasive standard for nodal assessment. For tumors ≥ 2 cm, neoadjuvant chemotherapy is being explored to enable fertility-sparing surgery but is not yet standard care. In advanced disease, ovarian transposition and cryopreservation safeguard ovarian function. Novel options such as uterine transposition and transplantation remain experimental. An individualized, multidisciplinary approach is key to balancing oncologic control and fertility preservation.</p>

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Fertilitätserhalt beim Zervixkarzinom

  • 期刊论文

  • 发表日期：

    2025年12月22日

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  • Dorothee Jakob,
  • Angeline Favre-Inhofer,
  • Hannes Endres,
  • Ingolf Juhasz-Böss,
  • Lisa Jung

摘要

Cervical cancer remains the fourth most common malignancy among women worldwide, frequently affecting patients of reproductive age. In early stages (Fédération Internationale de Gynécologie et d’Obstétrique [FIGO] IA–IB1), conization, simple, or radical trachelectomy can preserve the uterus and fertility. Sentinel lymph node mapping has become the minimally invasive standard for nodal assessment. For tumors ≥ 2 cm, neoadjuvant chemotherapy is being explored to enable fertility-sparing surgery but is not yet standard care. In advanced disease, ovarian transposition and cryopreservation safeguard ovarian function. Novel options such as uterine transposition and transplantation remain experimental. An individualized, multidisciplinary approach is key to balancing oncologic control and fertility preservation.