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<p>Labour-inhibiting drugs have been used for decades and are firmly established in everyday clinical practice. However, the expectation that the use of tocolysis would reduce the premature birth rate and improve perinatal outcome has not been confirmed in systematic studies. The only confirmed effect is the higher rate of patients in whom tocolysis is successful in prolonging the pregnancy beyond 48&#xa0;h and in whom complete lung maturation can be achieved. Tocolysis beyond 48&#xa0;h provides no benefit and is therefore no longer recommended. The drugs of choice are atosiban and nifedipine, alternatively indomethacin and glyerol trinitrate. Fenoterol should no longer be used to prolong pregnancy due to its significantly less favourable side effect profile but remains indispensable as an emergency medication during labour.</p>

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Stellenwert der Tokolyse bei vorzeitiger Wehentätigkeit

  • 期刊论文

  • 发表日期：

    2025年9月18日

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  • Dieter Grab,
  • Beate Hüner

摘要

Labour-inhibiting drugs have been used for decades and are firmly established in everyday clinical practice. However, the expectation that the use of tocolysis would reduce the premature birth rate and improve perinatal outcome has not been confirmed in systematic studies. The only confirmed effect is the higher rate of patients in whom tocolysis is successful in prolonging the pregnancy beyond 48 h and in whom complete lung maturation can be achieved. Tocolysis beyond 48 h provides no benefit and is therefore no longer recommended. The drugs of choice are atosiban and nifedipine, alternatively indomethacin and glyerol trinitrate. Fenoterol should no longer be used to prolong pregnancy due to its significantly less favourable side effect profile but remains indispensable as an emergency medication during labour.