Scholarlink

<p>Premature ovarian insufficiency (POI) is the result of a premature restriction of ovarian function. The diagnosis is based on the age of the patient (&lt; 40&#xa0;years old), on an increase in gonadotropins (follicle stimulating hormone, FSH &gt; 25 IU/l) and on oligomenorrhea or amenorrhea, which has persisted for at least 4 months. A differentiation is made between iatrogenic-induced and noniatrogenic POI. Noniatrogenic POI can have genetic or autoimmune origins. In 70–90% of cases, no cause can currently be determined (idiopathic). The first clinical symptoms of POI are menstrual cycle disorders. If hormonal substitution is not carried out the estrogen deficiency leads to increased morbidity and mortality in affected women, which is primarily due to the increased cardiovascular risk. Additionally, early estrogen deficiency can have substantial negative effects on bone density, muscle strength and muscle mass as well as cognition. The most important treatment is therefore the initiation of hormone substitution, at least until the natural menopausal age. This should be prescribed individually according to the risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prämature ovarielle Insuffizienz

  • 期刊论文

  • 发表日期：

    2025年7月25日

查看全文
  • Sabine Segerer

摘要

Premature ovarian insufficiency (POI) is the result of a premature restriction of ovarian function. The diagnosis is based on the age of the patient (< 40 years old), on an increase in gonadotropins (follicle stimulating hormone, FSH > 25 IU/l) and on oligomenorrhea or amenorrhea, which has persisted for at least 4 months. A differentiation is made between iatrogenic-induced and noniatrogenic POI. Noniatrogenic POI can have genetic or autoimmune origins. In 70–90% of cases, no cause can currently be determined (idiopathic). The first clinical symptoms of POI are menstrual cycle disorders. If hormonal substitution is not carried out the estrogen deficiency leads to increased morbidity and mortality in affected women, which is primarily due to the increased cardiovascular risk. Additionally, early estrogen deficiency can have substantial negative effects on bone density, muscle strength and muscle mass as well as cognition. The most important treatment is therefore the initiation of hormone substitution, at least until the natural menopausal age. This should be prescribed individually according to the risk.