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<p>In the second trimester of pregnancy, it is essential to refer patients at an increased risk of preeclampsia and those with typical preeclampsia symptoms for a&#xa0;comprehensive differential diagnostic assessment and monitoring. The objective is now no longer secondary prevention, but rather prediction of the severity and dynamics of preeclampsia. In addition to standard laboratory markers, angiogenic factors such as soluble fms-like tyrosine kinase receptor‑1 (sFlt-1) and placental growth factor (PlGF) are of particular relevance. Since various organ manifestations of preeclampsia can occur in addition to the obligatory hypertension, the clinical presentation can vary greatly. A&#xa0;secure differential diagnosis is thus essential to avoid severe maternal and fetal complications and to determine the ideal time for delivery.</p>

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Diagnostik der Präeklampsie ab dem zweiten Trimester – Bedeutung von sFlt-1 und PlGF

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Julia Franke,
  • Holger Stepan

摘要

In the second trimester of pregnancy, it is essential to refer patients at an increased risk of preeclampsia and those with typical preeclampsia symptoms for a comprehensive differential diagnostic assessment and monitoring. The objective is now no longer secondary prevention, but rather prediction of the severity and dynamics of preeclampsia. In addition to standard laboratory markers, angiogenic factors such as soluble fms-like tyrosine kinase receptor‑1 (sFlt-1) and placental growth factor (PlGF) are of particular relevance. Since various organ manifestations of preeclampsia can occur in addition to the obligatory hypertension, the clinical presentation can vary greatly. A secure differential diagnosis is thus essential to avoid severe maternal and fetal complications and to determine the ideal time for delivery.