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<p>Ribosomal fluorescence in situ hybridization (FISH) shows that bacterial vaginosis (BV) is a&#xa0;complex clinical syndrome comprising several unrelated infectious processes with similar symptoms. Biofilm vaginosis is the most common cause of BV syndrome, followed by cohesive <i>Lactobacillus iners</i> sludge vaginosis. Bacterial vaginosis syndrome also includes forms of dysbiosis that have not yet been clearly characterized, although it cannot be ruled out that these will later be subdivided into further, clearly nosologically defined groups. At present, pathogenic consortia can only be determined using ribosomal FISH. Neither light microscopy nor multiplex polymerase chain reaction (PCR) and next-generation sequencing (NGS) are helpful for this, as they only reveal the morphotypes or species involved and not their interrelationships. Since all polymicrobial communities rely on specific genes that are necessary for cohesion of the microorganisms involved, it is only a&#xa0;matter of time before these DNA sequences are decoded and their detection becomes accessible for clinical diagnostics and treatment.</p>

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Bakterielle Vaginose – ein Syndrom zwischen gestern und heute

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月14日

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  • Alexander Swidsinski,
  • Sonja Swidsinski,
  • Werner Mendling,
  • Alex Farr,
  • Yvonne Dörffel

摘要

Ribosomal fluorescence in situ hybridization (FISH) shows that bacterial vaginosis (BV) is a complex clinical syndrome comprising several unrelated infectious processes with similar symptoms. Biofilm vaginosis is the most common cause of BV syndrome, followed by cohesive Lactobacillus iners sludge vaginosis. Bacterial vaginosis syndrome also includes forms of dysbiosis that have not yet been clearly characterized, although it cannot be ruled out that these will later be subdivided into further, clearly nosologically defined groups. At present, pathogenic consortia can only be determined using ribosomal FISH. Neither light microscopy nor multiplex polymerase chain reaction (PCR) and next-generation sequencing (NGS) are helpful for this, as they only reveal the morphotypes or species involved and not their interrelationships. Since all polymicrobial communities rely on specific genes that are necessary for cohesion of the microorganisms involved, it is only a matter of time before these DNA sequences are decoded and their detection becomes accessible for clinical diagnostics and treatment.