<p><?tk 4?>Pesticides pose a significant threat to soil ecosystems worldwide due to their widespread use in agricultural practices. Bioremediation offers a sustainable solution by leveraging the natural capabilities of microorganisms. This study explores the efficacy of <i>Chlorella vulgaris</i> in remediating dimethoate and atrazine contamination in soil environments. Culturing <i>C. vulgaris</i> in a pesticide-contaminated soil slurry revealed a dose-dependent increase in removal efficiency, peaking at a 1.0 mgL⁻¹ concentration for both pesticides. Moreover, contact time significantly influenced removal rates, with 40% dimethoate and 45.5% atrazine removal achieved after 14 days. Optimal microalgal dosage (10 mL) yielded the highest removal efficiencies, indicating a saturation effect beyond this threshold. High-performance liquid chromatography analysis confirmed notable reductions in pesticide concentrations post-bioremediation. Response Surface Methodology analyses further validated the model’s significance and suitability for predicting removal efficiencies, highlighting the robustness of the bioremediation process. Findings underscore the potential of <i>C. vulgaris</i> as a cost-effective and environmentally friendly approach for mitigating pesticide contamination in agricultural soils. Future research should focus on elucidating the underlying mechanisms driving observed trends to further optimize bioremediation strategies.</p> Graphical abstract <p></p>