Scholarlink

<p>Male infertility has become an important concern, with environmental factors playing a significant role. Most studies have focused on single or similar types of environmental endocrine-disrupting chemicals (EDCs) in male infertility, despite human exposure to their complex mixtures. However, the contribution of each chemical remains unclear, and the role of nutrients in mitigating reproductive health effects from chemical exposure is not well understood. This study analyzed NHANES 2013–2016 data (<i>n</i> = 1,455) to examine relationships between exposure to 24 chemicals, 21 nutrients, and sex steroid hormones. Linear regression showed negative associations between phthalate metabolites and total testosterone (TT). Mixture analyses using weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) confirmed this, identifying propylparaben, mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and triclosan as key chemicals. Sufficient zinc, calcium, vitamin C, and vitamin E intake alleviated reproductive hormone dysfunction. Participants in the lowest quartile of zinc intake exhibited the most significant changes in TT and estradiol (E<sub>2</sub>) compared to those in the highest quartile. These findings suggest nutrient intake may be associated with attenuation of effects of EDC exposure on sex hormones.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Can Nutrition Intake Counteract Harmful Impact of Endocrine Disruptors on Male Sex Hormones? Insights from NHANES 2013–2016

  • 期刊论文

  • 发表日期：

    2025年10月22日

查看全文
  • Min Nian,
  • Jie Xiang,
  • Peiwei Xu,
  • Ling Tan,
  • Zhijian Chen,
  • Mingliang Fang

摘要

Male infertility has become an important concern, with environmental factors playing a significant role. Most studies have focused on single or similar types of environmental endocrine-disrupting chemicals (EDCs) in male infertility, despite human exposure to their complex mixtures. However, the contribution of each chemical remains unclear, and the role of nutrients in mitigating reproductive health effects from chemical exposure is not well understood. This study analyzed NHANES 2013–2016 data (n = 1,455) to examine relationships between exposure to 24 chemicals, 21 nutrients, and sex steroid hormones. Linear regression showed negative associations between phthalate metabolites and total testosterone (TT). Mixture analyses using weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) confirmed this, identifying propylparaben, mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and triclosan as key chemicals. Sufficient zinc, calcium, vitamin C, and vitamin E intake alleviated reproductive hormone dysfunction. Participants in the lowest quartile of zinc intake exhibited the most significant changes in TT and estradiol (E2) compared to those in the highest quartile. These findings suggest nutrient intake may be associated with attenuation of effects of EDC exposure on sex hormones.