Scholarlink

<p>Tin, a heavy metal, in trace amounts is believed to play various roles in the biological development of fish, including involvement in cell structure, enzyme activities, and the metabolism of proteins and carbohydrates. Two endocrine-disrupting chemicals, Tributyltin (TBT) and Triphenyltin (TPT), are prevalent in aquatic environments. This study examines the bioaccumulation of these compounds and their impact on oxidative stress enzymes. Zebrafish embryos were used to assess the acute toxicity of TBT, TPT, and SnCl<sub>2</sub>. Toxicity tests were conducted on fertilized eggs using different concentrations of TBT, TPT, and SnCl<sub>2</sub> (0, 1, 5, 10, 15, and 20 ng/L). The LC<sub>50, 96&#xa0;h</sub> values for TBT, TPT, and SnCl<sub>2</sub> in zebrafish embryos were 4.2, 8.7, and 12.56 ng/L, respectively. The study found an increase in the catalase (CAT) superoxide dismutase (SOD), and malondialdehyde (MDA) for TBT, TPT, and SnCl<sub>2</sub>. Moreover, TBT showed higher bioaccumulation than other compounds. The mortality rate was higher in embryos exposed to TBT, suggesting that embryos are more susceptible to TBT and can induce oxidative stress and disrupt the antioxidant equilibrium..</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bioaccumulation and Oxidative Stress Induced by Organometallic and Ionic Tin Compounds in Zebrafish (Danio rerio) Embryos

  • 期刊论文

  • 发表日期：

    2025年4月1日

查看全文
  • Jalal Hassan,
  • Aref Barkhordari,
  • Mohammad Kazem Koohi,
  • Ali pourshaban-shahrestani,
  • Hooman Rahmati-Holasoo,
  • Mohammad Amrollahi Sharifabadi

摘要

Tin, a heavy metal, in trace amounts is believed to play various roles in the biological development of fish, including involvement in cell structure, enzyme activities, and the metabolism of proteins and carbohydrates. Two endocrine-disrupting chemicals, Tributyltin (TBT) and Triphenyltin (TPT), are prevalent in aquatic environments. This study examines the bioaccumulation of these compounds and their impact on oxidative stress enzymes. Zebrafish embryos were used to assess the acute toxicity of TBT, TPT, and SnCl2. Toxicity tests were conducted on fertilized eggs using different concentrations of TBT, TPT, and SnCl2 (0, 1, 5, 10, 15, and 20 ng/L). The LC50, 96 h values for TBT, TPT, and SnCl2 in zebrafish embryos were 4.2, 8.7, and 12.56 ng/L, respectively. The study found an increase in the catalase (CAT) superoxide dismutase (SOD), and malondialdehyde (MDA) for TBT, TPT, and SnCl2. Moreover, TBT showed higher bioaccumulation than other compounds. The mortality rate was higher in embryos exposed to TBT, suggesting that embryos are more susceptible to TBT and can induce oxidative stress and disrupt the antioxidant equilibrium..