Purpose <p>Families experience a significant burden caring for their relatives with Schizophrenia The nature and degree of burden could vary across cultures in relation to the family structure and dynamics, economic status and access to health and welfare service This study aimed to examine similarities and differences in the experience of burden by family members (FM) caring for persons with Schizophrenia (PwS) in two countries, Australia and India that differ in their cultural, economic status, and health and welfare services.</p> Methods <p>A thematic analysis of individual in-depth interviews of 33 FMs, 12 from Australia and 22 from India, caring for persons with enduring Schizophrenia. The comparable and contrasting experiences of the families in the two countries were identified and discussed.</p> Results <p>Five themes comprising 13 subthemes emerged from the data. Experiences of psychological distress and its effect on mental health, devastation and trauma, and concerns over future care of PwS in the absence of FMs were expressed by both Australian and Indian FMs. Financial difficulties impacting caregiving and concerns over the PwS’s marriage were experienced only by the Indian families.</p> Conclusion <p>The caregiving experiences of families of persons with enduring Schizophrenia in Australia and India were mainly comparable. Some distinctive issues faced by the Indian families were related to economic and cultural factors. Family interventions to promote their well-being and caregiving capacity should be trauma-informed, address the individual needs, and be culturally sensitive.</p>