Scholarlink

Purpose <p>Social isolation, loneliness, and fine particulate matter (PM<sub>2.5</sub>) exposure are significant social and environmental factors that frequently cooccur in vulnerable populations. The joint effects of these factors on the risk of cardiovascular disease (CVD), however, are not well supported by data. This study aimed to evaluate the independent and combined effects of social isolation, loneliness, and long-term PM<sub>2.5</sub> exposure on CVD risk and to assess the interactions between social isolation or loneliness and PM<sub>2.5</sub> exposure on CVD risk.</p> Methods <p>We used Cox proportional hazards models to estimate the independent and combined effects of loneliness, social isolation, and long-term PM<sub>2.5</sub> exposure on CVD incidence. We also conducted interaction analyses to investigate whether the effects of social factors on CVD are modified by the level of PM<sub>2.5</sub> exposure.</p> Results <p>This study included 12,544 participants, with mean age of 58.7 ± 9.4 years. The median follow-up was 7 years, with 1761 CVD events occurred. Individuals with loneliness presented a 29% increased risk of CVD (hazard ratio [HR] = 1.290, 95% confidence intervals [CI]: 1.165–1.428). A 10&#xa0;µg/m<sup>3</sup> increase in PM<sub>2.5</sub> exposure was associated with a 6% increase in CVD risk (HR = 1.060, 95% CI: 1.028–1.092). A significant additive interaction effect was observed between loneliness and PM<sub>2.5</sub> on CVD (<i>P</i> for additive interaction = 0.042).</p> Conclusion <p>Among Chinese middle and older adults, loneliness and long-term PM<sub>2.5</sub> exposure had combined effects on CVD risk. The public health consequences of high PM<sub>2.5</sub> exposure are more pronounced among individuals who experience feelings of loneliness.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Combined effects of social health and long-term exposure to fine particulate matter on cardiovascular disease in Chinese middle-aged and older adults

  • 期刊论文

  • 发表日期：

    2025年4月21日

查看全文
  • Wei Li,
  • Yunxiao Yang,
  • Shuai Guo,
  • Jiayi Yi,
  • Chen Li,
  • Geng Shen,
  • Lin Wang,
  • Xiuhuan Chen,
  • Zhaogong Zhi,
  • Hai Gao

摘要

Purpose

Social isolation, loneliness, and fine particulate matter (PM2.5) exposure are significant social and environmental factors that frequently cooccur in vulnerable populations. The joint effects of these factors on the risk of cardiovascular disease (CVD), however, are not well supported by data. This study aimed to evaluate the independent and combined effects of social isolation, loneliness, and long-term PM2.5 exposure on CVD risk and to assess the interactions between social isolation or loneliness and PM2.5 exposure on CVD risk.

Methods

We used Cox proportional hazards models to estimate the independent and combined effects of loneliness, social isolation, and long-term PM2.5 exposure on CVD incidence. We also conducted interaction analyses to investigate whether the effects of social factors on CVD are modified by the level of PM2.5 exposure.

Results

This study included 12,544 participants, with mean age of 58.7 ± 9.4 years. The median follow-up was 7 years, with 1761 CVD events occurred. Individuals with loneliness presented a 29% increased risk of CVD (hazard ratio [HR] = 1.290, 95% confidence intervals [CI]: 1.165–1.428). A 10 µg/m3 increase in PM2.5 exposure was associated with a 6% increase in CVD risk (HR = 1.060, 95% CI: 1.028–1.092). A significant additive interaction effect was observed between loneliness and PM2.5 on CVD (P for additive interaction = 0.042).

Conclusion

Among Chinese middle and older adults, loneliness and long-term PM2.5 exposure had combined effects on CVD risk. The public health consequences of high PM2.5 exposure are more pronounced among individuals who experience feelings of loneliness.