<p>To investigate the evolutionary processes and associated mineralization characteristics of spodumene pegmatites in the Himalayan region, we present cathodoluminescence, oxygen isotope, and trace element results for quartz from the newly discovered Qiongjiagang pegmatite-type lithium deposit in the Himalaya. Quartz samples from different lithologies were all homogeneous and unzoned according to cathodoluminescence images. Quartz trace element characteristics indicate that Qiongjiagang spodumene pegmatites were formed from highly evolved melts with early fluid exsolution. The fluid exsolution stage governed the trace element composition of hydrothermal quartz. The oxygen isotope values of quartz from tourmaline-muscovite granites (14.5‰), barren pegmatites (14.3‰), and spodumene pegmatites (14.9‰) demonstrate that the pegmatites and granites share a comagmatic evolutionary origin, closely related to the partial melting of Higher Himalayan metasedimentary rocks. Beryl in the spodumene pegmatite has significantly elevated δ¹⁸O values (18.9‰) and significant isotopic disequilibrium (Δ _{quartz−beryl}=-2.8‰). We proposed that metamorphic fluids were likely involved in the formation of spodumene pegmatite. Our results suggest that there are quartz geochemical indicators that may be of specific use in exploration for Li resources in the Himalayan region including Al &gt; 300 µgg^− 1, Li &gt; 70 µgg^− 1, B &gt; 4 µgg^− 1, as well as ratios like Al/Ti (&gt; 30) and Ge/Ti (&gt; 0.2).</p>