Scholarlink

Aims/hypothesis <p>The aim of this study was to assess the frequency and metabolic characteristics of post-OGTT hypoglycaemia during an OGTT in individuals newly diagnosed with type 2 diabetes.</p> Methods <p>We analysed 97 extended (180 min) 75 g OGTTs from individuals newly diagnosed with type 2 diabetes. Glucose, insulin and C-peptide were measured at fasting and post-challenge time points. Insulin sensitivity was assessed using the oral glucose insulin sensitivity (OGIS) index and beta cell function was measured using the insulinogenic index (IGI) and Stumvoll’s second-phase index. All participants were assigned to the Ahlqvist diabetes clusters.</p> Results <p>Post-OGTT hypoglycaemia (glucose ≤3.9 mmol/l at 180 min) occurred in 8.2% of the OGTTs analysed. Compared with individuals without hypoglycaemia, individuals with post-OGTT hypoglycaemia had a significantly lower BMI and higher insulin sensitivity, without differences in beta cell function. All individuals with hypoglycaemia were assigned to the mild obesity- or age-related diabetes Ahlqvist clusters.</p> Conclusions/interpretation <p>Post-OGTT hypoglycaemia is present in a subset of individuals newly diagnosed with type 2 diabetes and is associated with higher insulin sensitivity.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Post-OGTT hypoglycaemia in newly diagnosed type 2 diabetes: frequency, characteristics and cluster assignment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月27日

查看全文
  • Rebecca Spies,
  • Gisa Ufer,
  • Roza Sabia,
  • Julia Hummel,
  • Andreas Peter,
  • Robert Wagner,
  • Martin Heni

摘要

Aims/hypothesis

The aim of this study was to assess the frequency and metabolic characteristics of post-OGTT hypoglycaemia during an OGTT in individuals newly diagnosed with type 2 diabetes.

Methods

We analysed 97 extended (180 min) 75 g OGTTs from individuals newly diagnosed with type 2 diabetes. Glucose, insulin and C-peptide were measured at fasting and post-challenge time points. Insulin sensitivity was assessed using the oral glucose insulin sensitivity (OGIS) index and beta cell function was measured using the insulinogenic index (IGI) and Stumvoll’s second-phase index. All participants were assigned to the Ahlqvist diabetes clusters.

Results

Post-OGTT hypoglycaemia (glucose ≤3.9 mmol/l at 180 min) occurred in 8.2% of the OGTTs analysed. Compared with individuals without hypoglycaemia, individuals with post-OGTT hypoglycaemia had a significantly lower BMI and higher insulin sensitivity, without differences in beta cell function. All individuals with hypoglycaemia were assigned to the mild obesity- or age-related diabetes Ahlqvist clusters.

Conclusions/interpretation

Post-OGTT hypoglycaemia is present in a subset of individuals newly diagnosed with type 2 diabetes and is associated with higher insulin sensitivity.

Graphical Abstract