Improving a hybrid from within itself
摘要
Improving a hybrid by transferring partially dominant alleles from one parent to the other is feasible if the median level of dominance is moderate and prediction accuracy is high.
AbstractConvergent improvement within a P1 × P2 single-cross hybrid attempts to transfer partially dominant favorable alleles from P1 to P2 and from P2 to P1. My objective in this simulation study was to determine if convergent improvement is a feasible procedure to develop a better single cross. Heterozygote effects (d) and homozygote effects (a) at quantitative trait loci (QTL) were resampled from an empirical distribution of genomewide marker estimates of d and a for maize (Zea mays L.) grain yield. The d values were scaled (d scale = 30%, 45%, and 60%) to account for the known upward bias when d/a ratios at markers are used to estimate d/a ratios at QTL. Convergent improvement led to positive responses to selection when only 30 QTL controlled the trait. When 250 QTL controlled the trait, convergent improvement led to a positive response when the d scale was 30% but not when the d scale was 60%. For the intermediate d scale of 45%, responses were positive in later backcross generations and when prediction accuracy was 0.60 or 0.80. The largest response was achieved with only one cycle of genomewide recurrent selection; additional cycles compromised the gains achieved from the final step of phenotypic selection among single crosses. Overall, the results suggested that success in convergent improvement is a possibility but not a certainty in maize, and that more consistent results would be expected in species such as rice (Oryza sativa L.) that show weaker heterosis than maize.