Scholarlink

Clinical issue <p>In recent decades, oncology has been fundamentally transformed by immune checkpoint inhibitors (ICIs). By blocking inhibitory molecules that normally inhibit T&#xa0;cell activation, they reactivate the body’s immune defenses against tumors.</p> Treatment innovations <p>ICIs have established themselves in numerous tumor types—from melanomas to lung and kidney carcinomas to tumor entities defined essentially by high mutational burden—they offer significant survival benefits.</p> Diagnostics <p>Radiology plays a&#xa0;central role in the management of these therapies, as phenomena such as pseudoprogression challenge the classic RECIST (response evaluation criteria in solid tumors) system, and early detection of immune-mediated side effects often precedes clinical manifestation in imaging.</p> Assessment <p>The growing complexity of therapy requires radiologists to possess precise image interpretation, interdisciplinary collaboration, and knowledge of immunological principles, thus, enabling an improved prognosis for many tumor types.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Übersicht zu Immuncheckpoint-Inhibitor-Therapien

  • 期刊论文

  • 发表日期：

    2025年12月11日

查看全文
  • Oliver Sedlaczek,
  • Heinz-Peter Schlemmer

摘要

Clinical issue

In recent decades, oncology has been fundamentally transformed by immune checkpoint inhibitors (ICIs). By blocking inhibitory molecules that normally inhibit T cell activation, they reactivate the body’s immune defenses against tumors.

Treatment innovations

ICIs have established themselves in numerous tumor types—from melanomas to lung and kidney carcinomas to tumor entities defined essentially by high mutational burden—they offer significant survival benefits.

Diagnostics

Radiology plays a central role in the management of these therapies, as phenomena such as pseudoprogression challenge the classic RECIST (response evaluation criteria in solid tumors) system, and early detection of immune-mediated side effects often precedes clinical manifestation in imaging.

Assessment

The growing complexity of therapy requires radiologists to possess precise image interpretation, interdisciplinary collaboration, and knowledge of immunological principles, thus, enabling an improved prognosis for many tumor types.