Scholarlink

<p>In the pharmacological treatment of mental disorders, gender-specific aspects are often ignored and guidelines also barely consider these aspects; however, male and female can react very differently to medications due to differences in pharmacokinetics and pharmacodynamics. This article provides an overview of gender-specific differences with a&#xa0;focus on the pharmacokinetics of psychotropic drugs. Furthermore, (life) phase-dependent differences are addressed considering the menstruation effect, the influence of oral contraceptives, pregnancy and menopause-related physiological alterations. Therapeutic drug monitoring (TDM) is a&#xa0;clinical instrument that can provide valuable contributions due to changing pharmacokinetics in order to optimize the efficacy and safety of pharmacotherapy in various phases of life.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Geschlechtsspezifische Aspekte bei der Psychopharmakotherapie

  • 期刊论文

  • 发表日期：

    2025年12月1日

查看全文
  • Georgios Schoretsanitis,
  • Chiara T. Schmidt,
  • Michael Paulzen

摘要

In the pharmacological treatment of mental disorders, gender-specific aspects are often ignored and guidelines also barely consider these aspects; however, male and female can react very differently to medications due to differences in pharmacokinetics and pharmacodynamics. This article provides an overview of gender-specific differences with a focus on the pharmacokinetics of psychotropic drugs. Furthermore, (life) phase-dependent differences are addressed considering the menstruation effect, the influence of oral contraceptives, pregnancy and menopause-related physiological alterations. Therapeutic drug monitoring (TDM) is a clinical instrument that can provide valuable contributions due to changing pharmacokinetics in order to optimize the efficacy and safety of pharmacotherapy in various phases of life.