<p>Plant diseases caused by diverse organisms are a constant risk to environmental sustainability and global food security. Understanding of plant immune systems is essential to control the plant diseases and increase the agricultural sustainability. Recent advances in spatial biology and single-cell technology have revolutionized the study of plant immune responses, offering a novel cell-state-specific gene regulator designate as primary immune responder (PRIMER) cells which provides a better insight of plant defense signaling mechanisms. These understandings open new possibilities for the scientists to develop advanced strategies to protect crops from diseases. This review provides an overview of emerging evidence on how PRIMER cells play as a warrior and revolutionizing plant immune responses. We also provide an insight that how PRIMER cells could be a central framework for translating single-cell plant immunity into sustainable and climate-resilient agricultural strategies. Further, several outstanding questions associated with the PRIMER cells are also discussed.</p>