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<p>Primary immunodeficiencies, also referred to as inborn errors of immunity, can present with rheumatic manifestations as a&#xa0;form of immune dysregulation. Both autoimmune and autoinflammatory processes can be involved. Identifying an underlying immunodeficiency is crucial for optimizing treatment, prophylaxis and monitoring of complications. Because immunodeficiencies are often diagnosed late in the context of rheumatic symptoms, atypical disease courses or additional clinical findings should always prompt consideration of an underlying immunological disorder.</p>

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Rheumatische Manifestationen von Primären Immundefekten

  • 期刊论文

  • 发表日期：

    2026年5月6日

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  • Susan Farmand,
  • Ulrich Baumann

摘要

Primary immunodeficiencies, also referred to as inborn errors of immunity, can present with rheumatic manifestations as a form of immune dysregulation. Both autoimmune and autoinflammatory processes can be involved. Identifying an underlying immunodeficiency is crucial for optimizing treatment, prophylaxis and monitoring of complications. Because immunodeficiencies are often diagnosed late in the context of rheumatic symptoms, atypical disease courses or additional clinical findings should always prompt consideration of an underlying immunological disorder.