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<p>An 8‑year-old girl with pre-existing pulmonary illness, chronic kidney disease and known colonization with multidrug-resistant <i>Pseudomonas aeruginosa </i>developed severe nosocomial pneumonia requiring mechanical ventilation. Due to the variable resistance patterns of previously cultured <i>Pseudomonas</i> isolates, cefiderocol was used as an off-label treatment following confirmed susceptibility testing of the strain isolated from tracheal secretions. The patient showed a&#xa0;rapid clinical and biochemical response during treatment, which was administered in parallel with continuous veno-venous hemofiltration (CVVH).</p>

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Erfolgreicher Einsatz von Cefiderocol bei nosokomialer Pneumonie mit MDR P. aeruginosa unter Nierenersatztherapie

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月15日

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  • Katrin Mehler,
  • Christina Taylan,
  • André Oberthuer,
  • Benjamin Kuehne,
  • Sandra Habbig

摘要

An 8‑year-old girl with pre-existing pulmonary illness, chronic kidney disease and known colonization with multidrug-resistant Pseudomonas aeruginosa developed severe nosocomial pneumonia requiring mechanical ventilation. Due to the variable resistance patterns of previously cultured Pseudomonas isolates, cefiderocol was used as an off-label treatment following confirmed susceptibility testing of the strain isolated from tracheal secretions. The patient showed a rapid clinical and biochemical response during treatment, which was administered in parallel with continuous veno-venous hemofiltration (CVVH).