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<p>Bronchopulmonary dysplasia (BPD) is a&#xa0;severe complication of premature birth that can be associated with pulmonary vascular changes and the development of pulmonary hypertension (BPD-PH). Impairment of alveolar diffusion, abnormal vascular remodeling and rarefication of pulmonary vessels (vascular growth cessation) lead to increased pulmonary vascular resistance and right heart failure. Approximately one quarter of all infants with moderate to severe BPD develop BPD-PH, which is associated with a high morbidity and mortality. The ongoing development of PH-specific pharmacotherapy provides new treatment options for infants with BPD-PH. Sildenafil has become the mainstay of modern BPD-PH treatment, while other medications, such as endothelin receptor antagonists and prostacyclin analogues/mimetics are increasingly being investigated; however, pediatric data from randomized controlled trials are currently scarce.</p>

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Bronchopulmonale-Dysplasie-assoziierte pulmonale Hypertonie

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月15日

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  • Martin Koestenberger,
  • Ernst Eber,
  • Gerhard Pichler,
  • Hannes Sallmon

摘要

Bronchopulmonary dysplasia (BPD) is a severe complication of premature birth that can be associated with pulmonary vascular changes and the development of pulmonary hypertension (BPD-PH). Impairment of alveolar diffusion, abnormal vascular remodeling and rarefication of pulmonary vessels (vascular growth cessation) lead to increased pulmonary vascular resistance and right heart failure. Approximately one quarter of all infants with moderate to severe BPD develop BPD-PH, which is associated with a high morbidity and mortality. The ongoing development of PH-specific pharmacotherapy provides new treatment options for infants with BPD-PH. Sildenafil has become the mainstay of modern BPD-PH treatment, while other medications, such as endothelin receptor antagonists and prostacyclin analogues/mimetics are increasingly being investigated; however, pediatric data from randomized controlled trials are currently scarce.