Scholarlink

<p>In the first months of a&#xa0;child’s life the human microbiome matures in interaction with the immune system and continuously increases in diversity. The human gut microbiome is involved in a&#xa0;large number of metabolic processes in the body and is an essential component for, e.g., the biosynthesis and modification of vitamins, hormones, neurotransmitters and the degradation of complex carbohydrates from the diet. Many studies have already shown that factors in early childhood, such as the birth, medication, diet or the environment, can have a&#xa0;direct impact on the development of the microbiome and influence its diversity and functionality. Epidemiological investigations from birth cohort studies revealed that initial perturbations in microbial maturation also correlate with pathological changes in later development and can increase the risk of allergic, metabolic or inflammatory diseases. Understanding early childhood microbiome development, such as the maturation of a&#xa0;functional organ could significantly improve our knowledge of disease pathogenesis and also point to therapeutic, diagnostic and preventive options.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Frühkindliches Mikrobiom

  • 期刊论文

  • 发表日期：

    2025年6月24日

查看全文
  • Patricia Maasjosthusmann,
  • Janina Soler Wenglein,
  • Eckard Hamelmann,
  • John Penders

摘要

In the first months of a child’s life the human microbiome matures in interaction with the immune system and continuously increases in diversity. The human gut microbiome is involved in a large number of metabolic processes in the body and is an essential component for, e.g., the biosynthesis and modification of vitamins, hormones, neurotransmitters and the degradation of complex carbohydrates from the diet. Many studies have already shown that factors in early childhood, such as the birth, medication, diet or the environment, can have a direct impact on the development of the microbiome and influence its diversity and functionality. Epidemiological investigations from birth cohort studies revealed that initial perturbations in microbial maturation also correlate with pathological changes in later development and can increase the risk of allergic, metabolic or inflammatory diseases. Understanding early childhood microbiome development, such as the maturation of a functional organ could significantly improve our knowledge of disease pathogenesis and also point to therapeutic, diagnostic and preventive options.