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<p>Malignant neoplasms constitute a&#xa0;major burden of morbidity and mortality in the general population. This necessitates intense screening of transplant candidates and even closer surveillance of immunosuppressed solid organ recipients. Active malignancy is an exclusion criterion to solid organ transplantation, with few exceptions, namely localized hepatic neoplasms. Accelerated tumor progression characterizes post-transplantation malignancies. Intensified surveillance is justified in elevated rates, e.g., of skin cancer and virus-associated neoplasms, especially Epstein–Barr virus-associated post-transplantation lymphoproliferative disease (PTLD). Renal cell cancer rates rise after kidney transplantation, predominantly affecting the native kidneys. Chemotherapeutic dose adjustments for renal and hepatic function pharmacokinetic interactions are frequent and require active monitoring. Immunotherapies pose new challenges by induction of allograft rejection. Data on management of immunosuppression are emerging. Individualized concepts need to take into account therapeutic options of both anti-cancer therapy and organ replacement.</p>

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Malignome und Transplantation

  • 期刊论文

  • 发表日期：

    2025年7月29日

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  • Sibylle von Vietinghoff,
  • Steffen Manekeller,
  • Guido Fechner,
  • Peter Brossart,
  • Jörg Kalff,
  • Manuel Ritter,
  • Christian P. Strassburg

摘要

Malignant neoplasms constitute a major burden of morbidity and mortality in the general population. This necessitates intense screening of transplant candidates and even closer surveillance of immunosuppressed solid organ recipients. Active malignancy is an exclusion criterion to solid organ transplantation, with few exceptions, namely localized hepatic neoplasms. Accelerated tumor progression characterizes post-transplantation malignancies. Intensified surveillance is justified in elevated rates, e.g., of skin cancer and virus-associated neoplasms, especially Epstein–Barr virus-associated post-transplantation lymphoproliferative disease (PTLD). Renal cell cancer rates rise after kidney transplantation, predominantly affecting the native kidneys. Chemotherapeutic dose adjustments for renal and hepatic function pharmacokinetic interactions are frequent and require active monitoring. Immunotherapies pose new challenges by induction of allograft rejection. Data on management of immunosuppression are emerging. Individualized concepts need to take into account therapeutic options of both anti-cancer therapy and organ replacement.