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<p>Antibiotics save lives, but their long-term side effects are often underestimated. To prevent side effects and maintain the effectiveness of antibiotics, uncomplicated infections should be treated as narrowly as possible, while life-threatening infections should be treated as broadly as necessary. Acute upper respiratory tract infections should only be treated with antibiotics if there is a&#xa0;clear bacterial cause and the infection is severe. Penicillin&#xa0;V is the first-line treatment for tonsillopharyngitis, amoxicillin for acute otitis media (AOM) and acute rhinosinusitis (ARS), and a&#xa0;group&#xa0;1 cephalosporin for furuncles and skin phlegmons. For severe infections with possible involvement of anaerobic bacteria (abscesses of the mouth and throat, oto- and sinogenic complications), aminopenicillin–beta-lactamase combination therapy is the first choice. Fluoroquinolones, cephalosporins (except group&#xa0;1), clindamycin, and carbapenems should only be used in well-founded exceptional cases.</p>

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S2k-Leitlinie Antibiotikatherapie von HNO-Infektionen

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Bernhard Olzowy

摘要

Antibiotics save lives, but their long-term side effects are often underestimated. To prevent side effects and maintain the effectiveness of antibiotics, uncomplicated infections should be treated as narrowly as possible, while life-threatening infections should be treated as broadly as necessary. Acute upper respiratory tract infections should only be treated with antibiotics if there is a clear bacterial cause and the infection is severe. Penicillin V is the first-line treatment for tonsillopharyngitis, amoxicillin for acute otitis media (AOM) and acute rhinosinusitis (ARS), and a group 1 cephalosporin for furuncles and skin phlegmons. For severe infections with possible involvement of anaerobic bacteria (abscesses of the mouth and throat, oto- and sinogenic complications), aminopenicillin–beta-lactamase combination therapy is the first choice. Fluoroquinolones, cephalosporins (except group 1), clindamycin, and carbapenems should only be used in well-founded exceptional cases.