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Background <p>Unilateral vocal fold paralysis (UVFP) often leads to considerable limitations in voice quality and voice-related quality of life. Medialization thyroplasty (MT) is an established procedure for voice rehabilitation in cases of glottic insufficiency. Since December 2019, the APrevent® Vocal Implant System (VOIS, APrevent Biotech, Vienna, Austria) has been available in Germany as the first secondarily adjustable implant.</p> Methods <p>A&#xa0;retrospective evaluation included 12&#xa0;patients who received MT with the VOIS implant. Voice quality was analyzed multidimensionally at timepoints T0 (preoperative), T1 (2–3&#xa0;months postoperatively), and T2 (6&#xa0;months postoperatively).</p> Results <p>Significant improvements were observed in all examined parameters. The mean maximum phonation time (MPT) increased from 5.79 s (T0) to 10.07 s at T1 (<i>p</i> &lt; 0.001) and to 13.22 s at T2 (<i>p</i> = 0.001). Maximum sound pressure level (SPLmax) increased from 77.08 to 86.09 dB at T1 (<i>p</i> = 0.004) and to 86.17 dB at T2 (<i>p</i> = 0.005). Perceptual voice quality, particularly breathiness, improved significantly from 2.29 to 0.73 at T1 (<i>p</i> = 0.004) and to 0.67 at T2 (<i>p</i> = 0.002). Additionally, there was a&#xa0;reduction in the VHI-12 score from 30.73 preoperatively to 11.29 at T1 (<i>p</i> = 0.016) and to 15.22 at T2 (<i>p</i> = 0.008). No significant changes were noted between T1 and T2.</p> Conclusion <p>Medialization thyroplasty with the VOIS implant resulted in significant improvements in voice quality and voice-related quality of life. The unique feature of the VOIS system, i.e., its secondary adjustability without a&#xa0;second surgery, offers potential for further optimization. Further studies are needed on the value of volume correction and the differential indications between MT and reinnervation techniques in UVFP.</p>

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Die Medialisierungsthyreoplastik mit dem VOIS-Implantat

  • 期刊论文

  • 发表日期：

    2025年5月20日

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  • Fabian Burk,
  • Gerhard Förster,
  • Kathleen Klinge,
  • Andreas H. Müller

摘要

Background

Unilateral vocal fold paralysis (UVFP) often leads to considerable limitations in voice quality and voice-related quality of life. Medialization thyroplasty (MT) is an established procedure for voice rehabilitation in cases of glottic insufficiency. Since December 2019, the APrevent® Vocal Implant System (VOIS, APrevent Biotech, Vienna, Austria) has been available in Germany as the first secondarily adjustable implant.

Methods

A retrospective evaluation included 12 patients who received MT with the VOIS implant. Voice quality was analyzed multidimensionally at timepoints T0 (preoperative), T1 (2–3 months postoperatively), and T2 (6 months postoperatively).

Results

Significant improvements were observed in all examined parameters. The mean maximum phonation time (MPT) increased from 5.79 s (T0) to 10.07 s at T1 (p < 0.001) and to 13.22 s at T2 (p = 0.001). Maximum sound pressure level (SPLmax) increased from 77.08 to 86.09 dB at T1 (p = 0.004) and to 86.17 dB at T2 (p = 0.005). Perceptual voice quality, particularly breathiness, improved significantly from 2.29 to 0.73 at T1 (p = 0.004) and to 0.67 at T2 (p = 0.002). Additionally, there was a reduction in the VHI-12 score from 30.73 preoperatively to 11.29 at T1 (p = 0.016) and to 15.22 at T2 (p = 0.008). No significant changes were noted between T1 and T2.

Conclusion

Medialization thyroplasty with the VOIS implant resulted in significant improvements in voice quality and voice-related quality of life. The unique feature of the VOIS system, i.e., its secondary adjustability without a second surgery, offers potential for further optimization. Further studies are needed on the value of volume correction and the differential indications between MT and reinnervation techniques in UVFP.