Scholarlink

<p>Chronic lymphedema is an inflammatory disease that in addition to a typical volume increase, also leads to changes in the skin and tissues. Cysts and fistulas are a&#xa0;direct consequence of the increased pressure in the lymphatic vessels, while pachydermia and papillomatosis are signs of the inflammatory process in the tissues. This inflammation causes, among other things, the release of various interleukins through the activation of hypoxia-inducible factor (HIF) from lymph endothelial cells, macrophages, Th1, Th2 and Th17 cells, leading to fibroadipose tissue transformation and a&#xa0;resulting reduction in immune function. To avoid these consequences, treatment of the inflammatory response should be considered in addition to complex decongestive therapy (CDT), as is the case with other fibrosing skin diseases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Hautveränderungen und Gewebereaktionen beim Lymphödem

  • 期刊论文

  • 发表日期：

    2026年3月16日

查看全文
  • Anya Miller

摘要

Chronic lymphedema is an inflammatory disease that in addition to a typical volume increase, also leads to changes in the skin and tissues. Cysts and fistulas are a direct consequence of the increased pressure in the lymphatic vessels, while pachydermia and papillomatosis are signs of the inflammatory process in the tissues. This inflammation causes, among other things, the release of various interleukins through the activation of hypoxia-inducible factor (HIF) from lymph endothelial cells, macrophages, Th1, Th2 and Th17 cells, leading to fibroadipose tissue transformation and a resulting reduction in immune function. To avoid these consequences, treatment of the inflammatory response should be considered in addition to complex decongestive therapy (CDT), as is the case with other fibrosing skin diseases.